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Aklomide

Name: Aklomide
Brand: TargetMol
SKU: T0390
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0390Cas No. 3011-89-0

Alias Alkomide, 2-Chloro-4-nitrobenzamide

Aklomide (2-Chloro-4-nitrobenzamide) is used in poultry to treat parasites.

Aklomide

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Purity: 99.65%

Catalog No. T0390Alias Alkomide, 2-Chloro-4-nitrobenzamideCas No. 3011-89-0

Aklomide (2-Chloro-4-nitrobenzamide) is used in poultry to treat parasites.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$35	In Stock	In Stock
500 mg	$56	In Stock	In Stock
1 g	$81	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.65%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Aklomide AI Summary

Aklomide exhibits a broad spectrum of bioactivity and inhibitory effects in various assays. It acts as an inhibitor of the MLL CXXC domain-DNA interaction with a potency of 50118.7 nM. In the context of malarial research, it functions as a delayed death inhibitor of the malarial parasite plastid, demonstrating potencies of 10691.0 nM and 19011.5 nM after 96-hour and 48-hour incubation assays, respectively. In virology, Aklomide blocks the entry of the Ebola virus with AC50 values ranging from 707.9 nM to 0.7079 µM. It also shows significant antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in Caco-2 and VERO-6 cells at a 10 µM concentration after 48 hours, with inhibition rates of 0.1% and -0.15%, respectively. The compound demonstrates 17.03% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. However, its IC50 value against SARS-CoV-2 in VERO-6 cells is greater than 19952.62 nM, indicating moderate to low potency. Additionally, a hit score of 0.1103 was reported in HRCE cells under specific conditions, suggesting potential efficacy. Moreover, Aklomide potently inhibits sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells at 10 µM with inhibition percentages of 100.21% and 115.49%, respectively. The compound also exhibits weak inhibition of the human BSEP transporter with an IC50 value greater than 1000000.0 nM, suggesting a limited effect on ATP-dependent [3H]-taurocholate transport. Lastly, in enzymatic assays for human HDAC6, it shows 8.11% and 3.17% inhibition using commercial and custom peptide substrates, respectively, indicating limited enzymatic inhibition activity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Aklomide (2-Chloro-4-nitrobenzamide) is used in poultry to treat parasites.
Synonyms	Alkomide, 2-Chloro-4-nitrobenzamide

Chemical Properties

Molecular Weight	200.58
Formula	C₇H₅ClN₂O₃
Cas No.	3011-89-0
Smiles	NC(=O)C1=C(Cl)C=C(C=C1)[N+]([O-])=O
Relative Density.	1.52 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (224.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (24.93 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9855 mL	24.9277 mL	49.8554 mL	249.2771 mL
5 mM	0.9971 mL	4.9855 mL	9.9711 mL	49.8554 mL
10 mM	0.4986 mL	2.4928 mL	4.9855 mL	24.9277 mL
20 mM	0.2493 mL	1.2464 mL	2.4928 mL	12.4639 mL
50 mM	0.0997 mL	0.4986 mL	0.9971 mL	4.9855 mL
100 mM	0.0499 mL	0.2493 mL	0.4986 mL	2.4928 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc