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Ethacrynic acid

Name: Ethacrynic acid
Brand: TargetMol
SKU: T4564
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T4564Cas No. 58-54-8

Alias Hydromedin, Etacrynic Acid, Edecrin

Ethacrynic acid (Edecrin) is a nonsulfonamide loop diuretic that inhibits the activity of the Na+/K+/2Cl- cotransporter NKCC2 in the thick ascending limb of the loop of Henle. It also inhibits glutathione S-transferase and Wnt signalling, producing cytotoxicity in chronic lymphocytic leukaemia cells and other tumour cells.

Ethacrynic acid

🥰Excellent

Purity: 99.85%

Catalog No. T4564Alias Hydromedin, Etacrynic Acid, EdecrinCas No. 58-54-8

Pack Size	Price	Availability
25 mg	$31	In Stock
50 mg	$44	In Stock
100 mg	$64	In Stock
500 mg	$148	In Stock
1 mL x 10 mM (in DMSO)	$32	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.85%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Ethacrynic acid (Edecrin) is a nonsulfonamide loop diuretic that inhibits the activity of the Na+/K+/2Cl- cotransporter NKCC2 in the thick ascending limb of the loop of Henle. It also inhibits glutathione S-transferase and Wnt signalling, producing cytotoxicity in chronic lymphocytic leukaemia cells and other tumour cells.
Synonyms	Hydromedin, Etacrynic Acid, Edecrin

Chemical Properties

Molecular Weight	303.14
Formula	C₁₃H₁₂Cl₂O₄
Cas No.	58-54-8
Smiles	CCC(=C)C(=O)C1=CC=C(OCC(O)=O)C(Cl)=C1Cl
Relative Density.	1.35g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 30 mg/mL (98.96 mM), Sonication is recommended.

DMSO: 50 mg/mL (164.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.6 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2988 mL	16.4940 mL	32.9881 mL	164.9403 mL
5 mM	0.6598 mL	3.2988 mL	6.5976 mL	32.9881 mL
10 mM	0.3299 mL	1.6494 mL	3.2988 mL	16.4940 mL
20 mM	0.1649 mL	0.8247 mL	1.6494 mL	8.2470 mL
50 mM	0.0660 mL	0.3299 mL	0.6598 mL	3.2988 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0330 mL	0.1649 mL	0.3299 mL	1.6494 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc