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4-Nonylphenylboronic acid
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Catalog No. T7688Cas No. 256383-45-6
4-Nonylphenylboronic acid is a inhibitor of FAAH.
4-Nonylphenylboronic acid
Copy Product Info🥰Excellent
Purity: 97.63%
Catalog No. T7688Cas No. 256383-45-6
4-Nonylphenylboronic acid is a inhibitor of FAAH.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 mg | $29 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:97.63%
Appearance:Solid
Color:White
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Product Introduction
4-Nonylphenylboronic acid AI Summary
4-Nonylphenylboronic acid is a multifunctional inhibitor with diverse biological activities. It notably inhibits the fatty acid amide hydrolase (FAAH) enzyme in Wistar rat brain with a potent IC50 of 9.1 nM and exerts inhibitory effects on the human recombinant monoacylglycerol lipase (MGL) enzyme with an IC50 of 7900.0 nM. It also targets lipid metabolism enzymes, exhibiting an IC50 of 1000.0 nM for human endothelial lipase and 42000.0 nM for human lipoprotein lipase in vesicle assays, with a selectivity ratio of 42.0. In micelle assays, it shows an IC50 of 100.0 nM for human endothelial lipase and 1400.0 nM for human lipoprotein lipase, with a selectivity ratio of 14.0. Additionally, it inhibits rat brain FAAH with an IC50 of 2920.0 nM and acts as an antagonist at recombinant human TRPV1 channels with an IC50 of 9100.0 nM, despite having less than 10.0% efficacy as an agonist at these channels. 4-Nonylphenylboronic acid has demonstrated antiviral bioactivity, showing a 24.57% inhibition of SARS-CoV-2 3CL-Pro protease and a modest inhibition rate of 1.29% against SARS-CoV-2 induced cytotoxicity in VERO-6 cells at a 10 µM concentration over 48 hours..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 4-Nonylphenylboronic acid is a inhibitor of FAAH. |
| Molecular Weight | 248.17 |
| Formula | C15H25BO2 |
| Cas No. | 256383-45-6 |
| Smiles | CCCCCCCCCc1ccc(cc1)B(O)O |
| Relative Density. | 0.97 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 9 mg/mL (36.27 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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