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N-acetyl Dapsone

Name: N-acetyl Dapsone
Brand: TargetMol
SKU: T35903
Price: 127 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35903Cas No. 565-20-8

N-acetyl Dapsone is an anti-inflammatory and antimicrobial compound widely used in the treatment of leprosy, malaria, acne and various immune disorders.

N-acetyl Dapsone

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Purity: 99.83%

Catalog No. T35903Cas No. 565-20-8

N-acetyl Dapsone is an anti-inflammatory and antimicrobial compound widely used in the treatment of leprosy, malaria, acne and various immune disorders.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$127	In Stock	In Stock
5 mg	$319	In Stock	In Stock
10 mg	$497	In Stock	In Stock
25 mg	$816	In Stock	In Stock
50 mg	$1,080	In Stock	In Stock
100 mg	$1,480	In Stock	In Stock
200 mg	$1,960	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.83%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

N-acetyl Dapsone AI Summary

N-acetyl Dapsone exhibits inhibitory activity against dihydropteroate synthase (SYN) from various microorganisms, showing moderate potency with the lowest IC50 against dihydropteroic acid synthase from Mycobacterium lufu, including DDS-resistant strains. This suggests its potential as an antifolate agent. The compound also shows inhibitory activity against Escherichia coli and Plasmodium berghei, albeit with higher IC50 values. In vitro, it inhibits Mycobacterium lufu's dihydropteroate synthase with a pC value of 5.15 and Escherichia coli's enzyme with an IC50 value of 5.75. Additionally, N-acetyl Dapsone exhibits various bioactivities: it activates and inhibits human muscle isoform 2 pyruvate kinase, modulates lipid storage in Drosophila cells, inhibits ELG1-dependent DNA repair in HEK293T cells, and induces DNA re-replication in various cell lines. It demonstrates antimycobacterial activity, being effective against DDS sensitive Mycobacterium smegmatis (MIC of 13.8 μg/mL) but not against DDS-resistant strains (MIC > 300 μg/mL). As an antimalarial, it prolongs survival in Plasmodium berghei-infected albino mice up to 3.5 weeks at a 400 mg/kg dose. In terms of pharmacokinetics and effects in rats, 50% of N-acetyl Dapsone is excreted in urine after 30 days of a single 400 mg/kg subcutaneous dose, with a half-life of 768 hours and a blood concentration of 1.3 μg/mL at the same dose. The compound shows activity against metallo-protein hemoglobin at 1.2 g/dL level post-administration at 400 mg/kg. Regarding anti-leprotic activity, it delays bacterial multiplication in the footpads of BALB/c mice infected with Mycobacterium leprae, starting at 60-75 days post-infection when administered at 0.01 g/100g of diet via feed for 90 days..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

N-acetyl Dapsone is an anti-inflammatory and antimicrobial compound widely used in the treatment of leprosy, malaria, acne and various immune disorders.

Chemical Properties

Molecular Weight	290.34
Formula	C₁₄H₁₄N₂O₃S
Cas No.	565-20-8
Smiles	S(=O)(=O)(C1=CC=C(NC(C)=O)C=C1)C2=CC=C(N)C=C2
Relative Density.	1.362 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (103.33 mM), Sonication is recommended.

DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL (1.72 mM), Sonication is recommended.

DMF: 30 mg/mL (103.33 mM), Sonication is recommended.

Solution Preparation Table

DMSO/DMF

	1mg	5mg	10mg	50mg
5 mM	0.6888 mL	3.4442 mL	6.8885 mL	34.4424 mL
10 mM	0.3444 mL	1.7221 mL	3.4442 mL	17.2212 mL
20 mM	0.1722 mL	0.8611 mL	1.7221 mL	8.6106 mL
50 mM	0.0689 mL	0.3444 mL	0.6888 mL	3.4442 mL
100 mM	0.0344 mL	0.1722 mL	0.3444 mL	1.7221 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc