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SPDP

Name: SPDP
Brand: TargetMol
SKU: T6741
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6741Cas No. 68181-17-9

Alias SPDP Crosslinker

SPDP is a short-chain crosslinker, which is used for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. SPDP could activate equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5).

SPDP

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Catalog No. T6741Alias SPDP CrosslinkerCas No. 68181-17-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$31	In Stock	-

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:>99.99%

Color:White

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COA HNMR

Product Introduction

Bioactivity

Description	SPDP is a short-chain crosslinker, which is used for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. SPDP could activate equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5).
Synonyms	SPDP Crosslinker

Chemical Properties

Molecular Weight	312.36
Formula	C₁₂H₁₂N₂O₄S₂
Cas No.	68181-17-9
Smiles	O=C(CCSSc1ccccn1)ON1C(=O)CCC1=O
Relative Density.	1.48 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (400.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2014 mL	16.0072 mL	32.0143 mL	160.0717 mL
5 mM	0.6403 mL	3.2014 mL	6.4029 mL	32.0143 mL
10 mM	0.3201 mL	1.6007 mL	3.2014 mL	16.0072 mL
20 mM	0.1601 mL	0.8004 mL	1.6007 mL	8.0036 mL
50 mM	0.0640 mL	0.3201 mL	0.6403 mL	3.2014 mL
100 mM	0.0320 mL	0.1601 mL	0.3201 mL	1.6007 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc