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SB-200646

Name: SB-200646
Brand: TargetMol
SKU: T8357
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8357Cas No. 143797-63-1

SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor

SB-200646

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Purity: 99.61%

Catalog No. T8357Cas No. 143797-63-1

SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$59	In Stock	In Stock
5 mg	$131	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$332	In Stock	In Stock
50 mg	$478	In Stock	In Stock
100 mg	$653	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$137	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.61%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

SB-200646 AI Summary

SB-200646 shows high binding affinity for the 5-HT2B receptor (Ki value of 21.0 nM) in rat stomach fundus, and moderate affinity for the 5-HT2C receptor, with very low affinity for the 5-HT2A receptor, suggesting a selectivity toward the 5-HT2B receptor. It exhibits multiple bioactivities, including inhibitory effects on various targets such as menin-MLL interactions in MLL-related leukemias, RECQ1 DNA helicase, human JMJD2E, tyrosyl-DNA phosphodiesterase, Tau fibril formation, Cruzain, Cytochrome P450 enzymes, and ROR gamma transcriptional activity. It also modulates lipid storage, blocks interactions between CBF-beta and RUNX1 in acute myeloid leukemia, and prevents cellular entry by Lassa and Marburg viruses. Additionally, SB-200646 shows antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells, with inhibition rates of -4.21% and 0.09% at 10 μM concentration after 48 hours respectively, and by inhibiting SARS-CoV-2 3CL-Pro protease activity by 18.71% at 20 μM. It also exhibits significant enzymatic inhibitory activity against human HDAC6, with inhibition percentages ranging from 39.59% to 88.14%, indicating its potential as an HDAC6 inhibitor. These bioactivities suggest that SB-200646 has diverse pharmacological effects related to serotonin receptor modulation, antiviral activity, and inhibition of key enzymatic pathways, offering potential therapeutic applications in various diseases and conditions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor
Targets&IC50	5-HT2B receptor:7.5 (pKi) , 5-HT2C receptor:6.9 (pKi) , 5-HT2A receptor:5.2 (pKi)

Chemical Properties

Molecular Weight	266.3
Formula	C₁₅H₁₄N₄O
Cas No.	143797-63-1
Smiles	CN1C=2C(=CC(NC(NC=3C=CC=NC3)=O)=CC2)C=C1
Relative Density.	1.26g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 53 mg/mL (199.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7552 mL	18.7758 mL	37.5516 mL	187.7582 mL
5 mM	0.7510 mL	3.7552 mL	7.5103 mL	37.5516 mL
10 mM	0.3755 mL	1.8776 mL	3.7552 mL	18.7758 mL
20 mM	0.1878 mL	0.9388 mL	1.8776 mL	9.3879 mL
50 mM	0.0751 mL	0.3755 mL	0.7510 mL	3.7552 mL
100 mM	0.0376 mL	0.1878 mL	0.3755 mL	1.8776 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc