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SB-200646

Name: SB-200646
Brand: TargetMol
SKU: T8357
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T8357Cas No. 143797-63-1

SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor

SB-200646

🥰Excellent

Purity: 99.61%

Catalog No. T8357Cas No. 143797-63-1

SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor

Pack Size	Price	Availability
1 mg	$98	In Stock
2 mg	$153	In Stock
5 mg	$218	In Stock
10 mg	$328	In Stock
25 mg	$553	In Stock
50 mg	$796	In Stock
100 mg	$1,090	In Stock
1 mL x 10 mM (in DMSO)	$228	In Stock

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Batch Information

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Purity:99.61%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor
Targets&IC50	5-HT2C receptor:6.9 (pKi) , 5-HT2A receptor:5.2 (pKi), 5-HT2B receptor:7.5 (pKi)

Chemical Properties

Molecular Weight	266.3
Formula	C₁₅H₁₄N₄O
Cas No.	143797-63-1
Smiles	CN1C=2C(=CC(NC(NC=3C=CC=NC3)=O)=CC2)C=C1
Relative Density.	1.26g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 53 mg/mL (199.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7552 mL	18.7758 mL	37.5516 mL	187.7582 mL
5 mM	0.7510 mL	3.7552 mL	7.5103 mL	37.5516 mL
10 mM	0.3755 mL	1.8776 mL	3.7552 mL	18.7758 mL
20 mM	0.1878 mL	0.9388 mL	1.8776 mL	9.3879 mL
50 mM	0.0751 mL	0.3755 mL	0.7510 mL	3.7552 mL
100 mM	0.0376 mL	0.1878 mL	0.3755 mL	1.8776 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc