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Anti-HCN3 Polyclonal Antibody
😃Good
Catalog No. TMAB-06918
Anti-HCN3 Polyclonal Antibody is a Rabbit antibody targeting HCN3. Anti-HCN3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-HCN3 Polyclonal Antibody
Anti-HCN3 Polyclonal Antibody
😃Good
Catalog No. TMAB-06918
Anti-HCN3 Polyclonal Antibody is a Rabbit antibody targeting HCN3. Anti-HCN3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-HCN3 Polyclonal Antibody is a Rabbit antibody targeting HCN3. Anti-HCN3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Cow,Horse,Rabbit) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Multi-pass membrane protein. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Hyperpolarization-activated, cyclic nucleotide-binding channels (HCN) are voltage-gated cation channels that are activated by direct binding of intracellular cyclic nucleotides. The HCN family consists of four members (HCN1-4), each with a core transmembrane segment domain and a C-terminal 120 amino-acid cyclic nucleotide-binding domain motif. HCN channels are expressed in the brain, heart, thalamus and testis. The pacemaker properties of HCN channels contribute to spontaneous rhythmic activity in the brain and heart. HCN3 contains a segment characterized by a series of positively charged amino acids at every third position. This region designated S4 is likely to be the voltage sensor of the protein. In the brain, HCN3 and HCN4 exhibit subcortical distribution mainly concentrated in the hypothalamus and thalamus, respectively. |
| Immunogen | KLH conjugated synthetic peptide: human HCN3 |
| Antigen Species | Human |
| Gene Name | HCN3 |
| Gene ID | |
| Protein Name | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 |
| Uniprot ID | |
| Function | Putative hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (By similarity). |
| Molecular Weight | Theoretical: 86 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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