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4'-O-Methylbavachalcone

Name: 4'-O-Methylbavachalcone
Brand: TargetMol
SKU: T3S0136
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3S0136Cas No. 20784-60-5

Alias O-Methylbroussochalcone B

4'-O-Methylbavachalcone (O-Methylbroussochalcone B) is isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity (IC50: 10.1 μM).

4'-O-Methylbavachalcone

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Purity: 99.92%

Catalog No. T3S0136Alias O-Methylbroussochalcone BCas No. 20784-60-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$36	In Stock	In Stock
5 mg	$84	In Stock	In Stock
10 mg	$147	In Stock	In Stock
25 mg	$248	In Stock	In Stock
50 mg	$369	In Stock	In Stock
100 mg	$543	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$100	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

Appearance:Solid

Color:Orange to Red

Resource Download

COA LCMS HNMR

Product Introduction

4'-O-Methylbavachalcone AI Summary

4'-O-Methylbavachalcone exhibits multi-faceted bioactivity. It shows notable cytotoxic effects against various human cancer cell lines, including MCF7, HCT116, PC3, and A549, with growth inhibitions of 73.0%, 63.0%, 44.0%, and 68.0% respectively, at 50 µM after 48 hours as measured by SRB assay. It also inhibits the SARS-CoV papain-like protease with an IC50 value of 4200.0 nM, assessed using the fluorescence method with Z-RLRGG-AMC as the substrate. Additionally, 4'-O-Methylbavachalcone demonstrates significant antibacterial activity against Bacillus subtilis, Staphylococcus epidermidis, and Micrococcus luteus, with a minimum inhibitory concentration (MIC) of 4.0 µg/mL. Moreover, it acts as an inhibitor of acetylcholinesterase (AChE) and beta-secretase 1 (BACE1), achieving 46.0% and 68.0% inhibition at a 100 µM concentration, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	4'-O-Methylbavachalcone (O-Methylbroussochalcone B) is isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity (IC50: 10.1 μM).
Targets&IC50	Plpro:10.1 μM
Synonyms	O-Methylbroussochalcone B

Chemical Properties

Molecular Weight	338.4
Formula	C₂₁H₂₂O₄
Cas No.	20784-60-5
Smiles	COc1cc(O)c(cc1CC=C(C)C)C(=O)\C=C\c1ccc(O)cc1
Relative Density.	1.181 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (354.61 mM), Sonication is recommended.

In Vivo Formulation

5% DMSO+40% PEG300+5% Tween 80+50% Saline/PBS: 6 mg/mL (17.73 mM)

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9551 mL	14.7754 mL	29.5508 mL	147.7541 mL
5 mM	0.5910 mL	2.9551 mL	5.9102 mL	29.5508 mL
10 mM	0.2955 mL	1.4775 mL	2.9551 mL	14.7754 mL
20 mM	0.1478 mL	0.7388 mL	1.4775 mL	7.3877 mL
50 mM	0.0591 mL	0.2955 mL	0.5910 mL	2.9551 mL
100 mM	0.0296 mL	0.1478 mL	0.2955 mL	1.4775 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc