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4'-O-Methylbavachalcone

🥰Excellent
Catalog No. T3S0136Cas No. 20784-60-5
Alias O-Methylbroussochalcone B

4'-O-Methylbavachalcone (O-Methylbroussochalcone B) is isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity (IC50: 10.1 μM).

4'-O-Methylbavachalcone

4'-O-Methylbavachalcone

🥰Excellent
Purity: 99.31%
Catalog No. T3S0136Alias O-Methylbroussochalcone BCas No. 20784-60-5
4'-O-Methylbavachalcone (O-Methylbroussochalcone B) is isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity (IC50: 10.1 μM).
Pack SizePriceAvailabilityQuantity
1 mg$36In Stock
5 mg$84In Stock
10 mg$147In Stock
25 mg$248In Stock
50 mg$369In Stock
100 mg$543In Stock
1 mL x 10 mM (in DMSO)$100In Stock
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Batch Information

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Purity:99.31%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
4'-O-Methylbavachalcone (O-Methylbroussochalcone B) is isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity (IC50: 10.1 μM).
Targets&IC50
Plpro:10.1 μM
SynonymsO-Methylbroussochalcone B
Chemical Properties
Molecular Weight338.4
FormulaC21H22O4
Cas No.20784-60-5
SmilesCOc1cc(O)c(cc1CC=C(C)C)C(=O)\C=C\c1ccc(O)cc1
Relative Density.1.181 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 30 mg/mL (88.65 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9551 mL14.7754 mL29.5508 mL147.7541 mL
5 mM0.5910 mL2.9551 mL5.9102 mL29.5508 mL
10 mM0.2955 mL1.4775 mL2.9551 mL14.7754 mL
20 mM0.1478 mL0.7388 mL1.4775 mL7.3877 mL
50 mM0.0591 mL0.2955 mL0.5910 mL2.9551 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

SARS-CoVSARSCoVSARS coronaviruspapain-like protease (PLpro)Inhibitorinhibit4'-O-Methylbavachalcone4'OMethylbavachalcone4' O Methylbavachalcone
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