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Amustaline dihydrochloride

Catalog No. T39548 CAS 210584-54-6

Synonyms: S-303 dihydrochloride

Amustaline (S-303) dihydrochloride is a nucleic acid-targeted alkylator recognized for its efficacy as a pathogen inactivation agent in blood components containing red blood cells. This compound comprises three key elements: an acridine anchor (a non-covalently bonding intercalator targeting nucleic acids), an effector (a bis-alkylator group that interacts with nucleophiles), and a linker (a flexible carbon chain with a labile ester bond, hydrolyzing at neutral pH to non-reactive products).

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Amustaline dihydrochloride Chemical Structure

Amustaline dihydrochloride, CAS 210584-54-6

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25 mg	Inquiry	$ 1,120.00
50 mg	Inquiry	$ 1,820.00
100 mg	Inquiry	$ 2,820.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Amustaline (S-303) dihydrochloride is a nucleic acid-targeted alkylator recognized for its efficacy as a pathogen inactivation agent in blood components containing red blood cells. This compound comprises three key elements: an acridine anchor (a non-covalently bonding intercalator targeting nucleic acids), an effector (a bis-alkylator group that interacts with nucleophiles), and a linker (a flexible carbon chain with a labile ester bond, hydrolyzing at neutral pH to non-reactive products).
In vitro	S-303 (200 μM; 20 h) and glutathione (GSH; 20 mM) effectively inactivate high levels of Chikungunya virus (CHIKV) in red blood cells (RBCs)[1]. Additionally, the combination of S-303 (200 μM; 20 h) and GSH at different concentrations demonstrates significant inactivation capabilities against various pathogens in whole blood and RBC experiments: it inactivates more than 6.5 logs of HIV, over 5.7 logs of Bluetongue virus, more than 7.0 logs of Yersinia enterocolitica, 4.2 logs of Serratia marcescens, and 7.5 logs of Staphylococcus epidermidis in whole blood[2], as well as roughly 5 logs or more of Y. enterocolitica, E. coli, S. marcescens, S. aureus, HIV, bovine viral diarrhoea virus, bluetongue virus, and human adenovirus 5 in RBCs[2]. Furthermore, S-303 maintains in vitro RBC function and physiology, preserving total ATP, extracellular potassium, hemolysis levels, glucose consumption, lactate production, and pH at 37 °C, aligning with conventional RBC standards[2].
In vivo	S‐303 RBCs, both in single transfusion doses of 50 μmol/kg for rats and 70 μmol/kg for dogs, and in repeated transfusion doses of 10 μmol/kg for both rats and dogs, have been found to be well tolerated. There is no histopathologic evidence of organ toxicity in these animals[3].

Synonyms	S-303 dihydrochloride
Molecular Weight	470.82
Formula	C22H26Cl3N3O2
CAS No.	210584-54-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Aubry M, et, al. Amustaline (S-303) treatment inactivates high levels of Chikungunya virus in red-blood-cell components. Vox Sang. 2018 Apr;113(3):232-241. 2. Mufti NA, et, al. Treatment of whole blood (WB) and red blood cells (RBC) with S-303 inactivates pathogens and retains in vitro quality of stored RBC. Biologicals. 2010 Jan;38(1):14-9. 3. North A, et, al. Preclinical pharmacokinetic and toxicology assessment of red blood cells prepared with S-303 pathogen inactivation treatment. Transfusion. 2011 Oct;51(10):2208-18.

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Keywords

Amustaline dihydrochloride 210584-54-6 S303 Dihydrochloride S-303 dihydrochloride S 303 Dihydrochloride S-303 Dihydrochloride S 303 S303 Amustaline S-303 Amustaline Dihydrochloride inhibitor inhibit

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