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TargetMol | Compound Library

Anti-Lung Cancer Compound Library

Catalog No. L2190

According to Global cancer statistics 2018, the global cancer burden is estimated to have risen to 18.1 million new cases and 9.6 million deaths in 2018. Nearly half of the new cases and more than half of the cancer deaths worldwide in 2018 are estimated to occur in Asia. Cancer of the lung is responsible for both the leading type of new cases (11.6% of the total cancer incidence) and the largest number of deaths (1.8 million deaths, 18.4% of the total) worldwide because of the poor prognosis for this cancer due to lack of effective therapy.

Treatment options for lung cancer include surgery, radiation therapy, chemotherapy, immunotherapy, targeted therapy and combination therapy. Therapeutic-modalities recommendations depend on several factors, including the type and stage of cancer. Despite the improvements in diagnosis and therapy made during the past 30 years, the prognosis for patients with lung cancer is still unsatisfactory. The responses to current standard therapies are poor except for the most localized cancers.

Targeted therapy and immunotherapy have changed the treatment paradigm of non-small cell lung cancer (NSCLC) and become the future direction for lung cancer therapy based on the major advances achieved recently. Targeted therapies focus on cancer cells by interrupting their growth and how they function and help reduce damage to healthy cells. However, while targeted therapy in NSCLC has provided disease control, the tumors inevitably develop drug resistance. With the advent of whole genome sequencing technology, we will have more understanding on the biological mechanism of the occurrence and development of NSCLC and the mechanism of drug resistance thus new generation of targeted therapy overcoming drug resistance can be designed and developed.

TargetMol's Anti-Lung Cancer Compound Library collects 2240 compounds targeting lung cancer's major signaling pathways or having anti-lung cancer therapeutic activity reported in literatures.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2190

Anti-Lung Cancer Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 2240 compounds with anti-lung cancer therapeutic activity or targeting lung cancer’s major signaling pathways, can be used for anti-lung cancer drug discovery and mechanism study;
  • Targets include EGFR, PI3K, FGFR, HER2, ALK, c-Met, etc.;
  • Some compounds have been in market or in clinical trials;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Apoptosis
Autophagy
NF-κB
PI3K
EGFR
VEGFR
JAK
mTOR
Akt
STAT
PDGFR
AMPK
FGFR
FLT
GSK-3
ALK
c-Met/HGFR
CDK
Wnt/beta-catenin
c-Kit
Antibacterial
Endogenous Metabolite
Src
p53
ERK
TGF-beta/Smad
COX
IGF-1R
DNA/RNA Synthesis
TNF
Tyrosine Kinases
DNA-PK
Potassium Channel
Parasite
ATM/ATR
Bcr-Abl
c-RET
HER
S6 Kinase
Antibiotic
HIV Protease
Raf
Mitophagy
p38 MAPK
Reactive Oxygen Species
IL Receptor
Pim
Aurora Kinase
HDAC
Microtubule Associated
Topoisomerase
PDK
PKC
TAM Receptor
Cytochromes P450
Ferroptosis
MEK
Dehydrogenase
Caspase
JNK
DNA Alkylator/Crosslinker
FAK
PPAR
Kras
Bcl-2 Family
PARP
Calcium Channel
Mdm2
Influenza Virus
MAPK
PI4K
c-Fms
DNA Alkylation
Lipoxygenase
NO Synthase
PKA
Trk receptor
5-HT Receptor
Antifungal
HSP
IκB/IKK
ROS
AChR
Casein Kinase
MMP
Nrf2
Phosphatase
ROS Kinase
Antioxidant
Chk
Interleukin
SARS-CoV
Syk
Beta Amyloid
Estrogen/progestogen Receptor
TLR
Adrenergic Receptor
Epigenetic Reader Domain
Histamine Receptor
NOS
Nucleoside Antimetabolite/Analog
PDE
Ras
ROCK
Sodium Channel
CSF-1R
Drug Metabolite
E1/E2/E3 Enzyme
HCV Protease
HIF/HIF Prolyl-Hydroxylase
HSV
P-gp
PTEN
SIK
Tyrosinase
ADC Cytotoxin
Adenosine Receptor
GABA Receptor
Glucocorticoid Receptor
Histone Methyltransferase
PLK
Prostaglandin Receptor
Sirtuin
Virus Protease
DHFR
DUB
DYRK
Estrogen Receptor/ERR
Gamma-secretase
Integrin
MELK
Mitochondrial Metabolism
RAAS
Antifection
Antifolate
Antiviral
CaMK
Cholinesterase (ChE)
GluR
HIF
Histone Demethylase
IAP
MRP
NOD
PROTACs
transporter
BTK
ATPase
CCR
DNA
Dopamine Receptor
Ephrin Receptor
Glucosidase
Hedgehog/Smoothened
Histone Acetyltransferase
LDL
MLK
NOD-like Receptor (NLR)
Opioid Receptor
Porcupine
Proteasome
PYK2
Retinoid Receptor
Rho
RIP kinase
SGK
Tie-2
ACK1
Anti-infection
Aromatase
Aryl Hydrocarbon Receptor
BACE
Cannabinoid Receptor
Chloride channel
Cholecystokinin Receptor
Discoidin Domain Receptor (DDR)
DNA Methyltransferase
Glutathione Peroxidase
HMG-CoA Reductase
IFNAR
IRAK
Lipid
NADPH
NMDAR
PERK
PGE Synthase
Reverse Transcriptase
Serine Protease
Transferase
ABC Transporter
Acyltransferase
Androgen Receptor
Beta-Secretase
Bombesin Receptor
cAMP
Carbonic Anhydrase
CXCR
DAPK
GHSR
Glucokinase
GST
GTPase
HBV
Hippo pathway
Immunology/Inflammation related
Indoleamine 2,3-Dioxygenase (IDO)
IRE1
Kinesin
Leukotriene Receptor
Ligand for E3 Ligase
Ligands for Target Protein for PROTAC
LTR
MNK
Molecular Glues
Monoamine Transporter
PD-1/PD-L1
Phospholipase
Progesterone Receptor
Reductase
ribosome
ROR
S1P Receptor
Serine/threonin kinase
Serotonin Transporter
Smo
STING
TRP/TRPV Channel
YAP
Adenosine Deaminase
Adenylyl Cyclase
Amino Acids and Derivatives
Aminopeptidase
ATP Citrate Lyase
BCRP
Cell Cycle Arrest
CFTR
c-Myc
Complement System
CRISPR/Cas9
CRM1
Decarboxylase
FAAH
Fatty Acid Synthase
Free radical scavengers
FXR
Gap Junction Protein
Glucagon Receptor
GluCls
Glutaminase
gp120/CD4
GPCR
Guanylate cyclase
hCE
Hck
Hexokinase
IDO
iGluR
KSP
Liver X Receptor
LRRK2
MALT
MAO
MDM-2/p53
Melanin-concentrating Hormone Receptor (MCHR)
Melatonin Receptor
Methionine Adenosyltransferase (MAT)
MicroRNA
Monoamine Oxidase
MTH1
MyD88
Myosin
Na+/Ca2+ Exchanger
NADPH-oxidase
NEDD8
Neurokinin receptor
Neuropeptide Y Receptor
Neurotensin Receptor
NPC1L1
OCT
OXPHOS
P2X Receptor
PAI-1
PAK
PKM
Platelet aggregation
Pyroptosis
RAR/RXR
RSV
Sigma receptor
Survivin
Thioredoxin
Thrombopoietin Receptor
TOPK
UGT
VDA
Wee1
Xanthine Oxidase
IGF-2R

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