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TargetMol | Compound Library

Anti-Lung Cancer Compound Library

Catalog No. L2190

According to Global cancer statistics 2018, the global cancer burden is estimated to have risen to 18.1 million new cases and 9.6 million deaths in 2018. Nearly half of the new cases and more than half of the cancer deaths worldwide in 2018 are estimated to occur in Asia. Cancer of the lung is responsible for both the leading type of new cases (11.6% of the total cancer incidence) and the largest number of deaths (1.8 million deaths, 18.4% of the total) worldwide because of the poor prognosis for this cancer due to lack of effective therapy.

Treatment options for lung cancer include surgery, radiation therapy, chemotherapy, immunotherapy, targeted therapy and combination therapy. Therapeutic-modalities recommendations depend on several factors, including the type and stage of cancer. Despite the improvements in diagnosis and therapy made during the past 30 years, the prognosis for patients with lung cancer is still unsatisfactory. The responses to current standard therapies are poor except for the most localized cancers.

Targeted therapy and immunotherapy have changed the treatment paradigm of non-small cell lung cancer (NSCLC) and become the future direction for lung cancer therapy based on the major advances achieved recently. Targeted therapies focus on cancer cells by interrupting their growth and how they function and help reduce damage to healthy cells. However, while targeted therapy in NSCLC has provided disease control, the tumors inevitably develop drug resistance. With the advent of whole genome sequencing technology, we will have more understanding on the biological mechanism of the occurrence and development of NSCLC and the mechanism of drug resistance thus new generation of targeted therapy overcoming drug resistance can be designed and developed.

TargetMol's Anti-Lung Cancer Compound Library collects 2240 compounds targeting lung cancer's major signaling pathways or having anti-lung cancer therapeutic activity reported in literatures.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2190

Anti-Lung Cancer Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 2240 compounds with anti-lung cancer therapeutic activity or targeting lung cancer’s major signaling pathways, can be used for anti-lung cancer drug discovery and mechanism study;
  • Targets include EGFR, PI3K, FGFR, HER2, ALK, c-Met, etc.;
  • Some compounds have been in market or in clinical trials;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Apoptosis
Autophagy
NF-κB
PI3K
EGFR
VEGFR
mTOR
JAK
Akt
STAT
PDGFR
AMPK
FLT
FGFR
GSK-3
c-Met/HGFR
Endogenous Metabolite
Antibacterial
Wnt/beta-catenin
ALK
CDK
Ras
c-Kit
Src
ERK
TGF-beta/Smad
p53
KRas
Parasite
COX
IGF-1R
TNF
DNA/RNA Synthesis
p38 MAPK
MDM-2/p53
Tyrosine Kinases
Potassium Channel
DNA-PK
S6 Kinase
Bcr-Abl
Raf
ATM/ATR
HIV Protease
Mitophagy
Reactive Oxygen Species
Antibiotic
c-RET
HER
Caspase
Cytochromes P450
Bcl-2 Family
Pim
IL Receptor
Aurora Kinase
PARP
Microtubule Associated
Dehydrogenase
PKC
HDAC
MEK
Ferroptosis
JNK
Topoisomerase
PDK
TAM Receptor
DNA Alkylator/Crosslinker
PPAR
FAK
Calcium Channel
Interleukin
NO Synthase
Influenza Virus
c-Fms
Mdm2
MMP
PI4K
Phosphatase
PKA
DNA Alkylation
MAPK
Trk receptor
Casein Kinase
IκB/IKK
ROS
Lipoxygenase
ROS Kinase
Antifungal
E1/E2/E3 Enzyme
HSP
SARS-CoV
5-HT Receptor
HSV
Nrf2
AChR
Estrogen/progestogen Receptor
Antioxidant
Virus Protease
PDE
Drug Metabolite
Chk
Epigenetic Reader Domain
TLR
Beta Amyloid
Syk
HIF/HIF Prolyl-Hydroxylase
ROCK
NOS
HCV Protease
Histamine Receptor
Estrogen Receptor/ERR
Nucleoside Antimetabolite/Analog
Adrenergic Receptor
PTEN
P-gp
Sodium Channel
Histone Methyltransferase
CSF-1R
SIK
GABA Receptor
Tyrosinase
ADC Cytotoxin
Integrin
Adenosine Receptor
DYRK
PERK
Tie-2
Glucocorticoid Receptor
Gamma-secretase
Glucosidase
Mitochondrial Metabolism
DUB
Prostaglandin Receptor
Sirtuin
Histone Acetyltransferase
PLK
ATPase
DHFR
Histone Demethylase
RAAS
Antifolate
IAP
Antifection
MELK
BTK
PROTACs
Reductase
MRP
Hedgehog/Smoothened
Cholinesterase (ChE)
GluR
CaMK
Antiviral
transporter
Retinoid Receptor
HIF
SGK
DNA Methyltransferase
NOD
NOD-like Receptor (NLR)
Proteasome
Dopamine Receptor
Rho
PYK2
iGluR
RIP kinase
LDL
Molecular Glues
Opioid Receptor
CCR
Angiotensin-converting Enzyme (ACE)
DNA
PGE Synthase
Porcupine
Ephrin Receptor
FKBP
Reverse Transcriptase
Cannabinoid Receptor
Anti-infection
MLK
PD-1/PD-L1
Chloride channel
Transferase
BACE
IFNAR
NADPH
Glutathione Peroxidase
c-Myc
Cholecystokinin Receptor
Serine Protease
Leukotriene Receptor
TRP/TRPV Channel
Aryl Hydrocarbon Receptor
NMDAR
ACK1
Lipid
Survivin
Hippo pathway
GST
Aromatase
Discoidin Domain Receptor (DDR)
IRAK
HMG-CoA Reductase
Monoamine Oxidase
GPCR
Proton pump
Carbonic Anhydrase
ROR
Ligands for Target Protein for PROTAC
YAP
LTR
GTPase
Progesterone Receptor
HBV
Photosensitizer
Serotonin Transporter
Serine/threonin kinase
FXR
Glucokinase
IDO
Immunology/Inflammation related
Prolyl Endopeptidase (PREP)
Myosin
IRE1
ABC Transporter
Monoamine Transporter
Smo
Bombesin Receptor
CXCR
cAMP
Indoleamine 2,3-Dioxygenase (IDO)
Androgen Receptor
ATP Citrate Lyase
OXPHOS
Beta-Secretase
MNK
Acyltransferase
STING
Pyroptosis
Ligand for E3 Ligase
ribosome
Phospholipase
GHSR
DAPK
S1P Receptor
IKZF
Melanin-concentrating Hormone Receptor (MCHR)
Adenylyl Cyclase
MicroRNA
NPC1L1
RAR/RXR
CD38
MALT
NEDD8
CRM1
MyD88
Amino Acids and Derivatives
Y Box Binding Protein 1
P2Y Receptor
Na+/Ca2+ Exchanger
gp120/CD4
TOPK
VDA
Melatonin Receptor
OCT
Galectin
Hck
Cell Cycle Arrest
Liver X Receptor
Neurotensin Receptor
Glutaminase
NR4A
RANKL/RANK
MAO
UGT
PAFR
MTH1
Glucagon Receptor
P2X Receptor
Na-K-Cl cotransporter
Hexokinase
Guanylate cyclase
Neuropeptide Y Receptor
Fatty Acid Synthase
Thioredoxin
PAK
FAAH
Stearoyl-CoA Desaturase (SCD)
Xanthine Oxidase
Thrombopoietin Receptor
Wee1
BCRP
LRRK2
Free radical scavengers
Aminopeptidase
AIM2
Decarboxylase
GluCls
hCE
PAI-1
RSV
Methionine Adenosyltransferase (MAT)
CRISPR/Cas9
Adenosine Deaminase
Cuproptosis
Complement System
Gap Junction Protein
Neurokinin receptor
Platelet aggregation
NADPH-oxidase
Sigma receptor
CFTR
Kinesin
PKM
IGF-2R

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