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TargetMol | Compound Library

Anti-Lung Cancer Compound Library

Catalog No. L2190

According to Global cancer statistics 2018, the global cancer burden is estimated to have risen to 18.1 million new cases and 9.6 million deaths in 2018. Nearly half of the new cases and more than half of the cancer deaths worldwide in 2018 are estimated to occur in Asia. Cancer of the lung is responsible for both the leading type of new cases (11.6% of the total cancer incidence) and the largest number of deaths (1.8 million deaths, 18.4% of the total) worldwide because of the poor prognosis for this cancer due to lack of effective therapy.

Treatment options for lung cancer include surgery, radiation therapy, chemotherapy, immunotherapy, targeted therapy and combination therapy. Therapeutic-modalities recommendations depend on several factors, including the type and stage of cancer. Despite the improvements in diagnosis and therapy made during the past 30 years, the prognosis for patients with lung cancer is still unsatisfactory. The responses to current standard therapies are poor except for the most localized cancers.

Targeted therapy and immunotherapy have changed the treatment paradigm of non-small cell lung cancer (NSCLC) and become the future direction for lung cancer therapy based on the major advances achieved recently. Targeted therapies focus on cancer cells by interrupting their growth and how they function and help reduce damage to healthy cells. However, while targeted therapy in NSCLC has provided disease control, the tumors inevitably develop drug resistance. With the advent of whole genome sequencing technology, we will have more understanding on the biological mechanism of the occurrence and development of NSCLC and the mechanism of drug resistance thus new generation of targeted therapy overcoming drug resistance can be designed and developed.

TargetMol's Anti-Lung Cancer Compound Library collects 2240 compounds targeting lung cancer's major signaling pathways or having anti-lung cancer therapeutic activity reported in literatures.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2190

Anti-Lung Cancer Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 2240 compounds with anti-lung cancer therapeutic activity or targeting lung cancer’s major signaling pathways, can be used for anti-lung cancer drug discovery and mechanism study;
  • Targets include EGFR, PI3K, FGFR, HER2, ALK, c-Met, etc.;
  • Some compounds have been in market or in clinical trials;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Apoptosis
Autophagy
NF-κB
PI3K
EGFR
VEGFR
JAK
mTOR
Akt
STAT
PDGFR
AMPK
FGFR
FLT
GSK-3
c-Met/HGFR
ALK
CDK
Wnt/beta-catenin
c-Kit
Antibacterial
Src
Endogenous Metabolite
p53
ERK
IGF-1R
TGF-beta/Smad
COX
DNA/RNA Synthesis
TNF
Tyrosine Kinases
DNA-PK
Potassium Channel
Parasite
ATM/ATR
Bcr-Abl
c-RET
S6 Kinase
HER
HIV Protease
Raf
Antibiotic
Mitophagy
p38 MAPK
Reactive Oxygen Species
Pim
IL Receptor
Aurora Kinase
HDAC
Microtubule Associated
Topoisomerase
PKC
PDK
TAM Receptor
Ferroptosis
Cytochromes P450
MEK
Dehydrogenase
JNK
Caspase
DNA Alkylator/Crosslinker
PPAR
FAK
Kras
PARP
Bcl-2 Family
Mdm2
Calcium Channel
PI4K
MAPK
Trk receptor
Influenza Virus
PKA
DNA Alkylation
Lipoxygenase
c-Fms
NO Synthase
Antifungal
ROS
HSP
IκB/IKK
5-HT Receptor
Phosphatase
MMP
Nrf2
Casein Kinase
AChR
ROS Kinase
Antioxidant
Chk
Interleukin
SARS-CoV
Syk
Estrogen/progestogen Receptor
Epigenetic Reader Domain
TLR
Beta Amyloid
NOS
HCV Protease
Histamine Receptor
Nucleoside Antimetabolite/Analog
ROCK
Adrenergic Receptor
PDE
Sodium Channel
Ras
CSF-1R
SIK
E1/E2/E3 Enzyme
Drug Metabolite
HSV
PTEN
P-gp
Tyrosinase
HIF/HIF Prolyl-Hydroxylase
ADC Cytotoxin
Histone Methyltransferase
Adenosine Receptor
Virus Protease
Glucocorticoid Receptor
Prostaglandin Receptor
Sirtuin
GABA Receptor
PLK
DHFR
Integrin
DYRK
RAAS
Estrogen Receptor/ERR
Gamma-secretase
Mitochondrial Metabolism
DUB
MELK
PROTACs
Histone Demethylase
MRP
Antifolate
IAP
Antifection
Cholinesterase (ChE)
GluR
Antiviral
transporter
Retinoid Receptor
HIF
NOD
BTK
Proteasome
ATPase
Dopamine Receptor
Tie-2
Rho
PYK2
RIP kinase
LDL
Glucosidase
Opioid Receptor
Hedgehog/Smoothened
CCR
CaMK
DNA
Porcupine
Ephrin Receptor
Histone Acetyltransferase
SGK
NOD-like Receptor (NLR)
MLK
Chloride channel
Transferase
BACE
IFNAR
NADPH
PERK
Glutathione Peroxidase
Cholecystokinin Receptor
Serine Protease
Aryl Hydrocarbon Receptor
NMDAR
ACK1
Lipid
PGE Synthase
Reverse Transcriptase
Aromatase
Cannabinoid Receptor
Discoidin Domain Receptor (DDR)
Anti-infection
DNA Methyltransferase
IRAK
HMG-CoA Reductase
Carbonic Anhydrase
ROR
Ligands for Target Protein for PROTAC
YAP
LTR
Reductase
GTPase
Progesterone Receptor
HBV
Photosensitizer
Serotonin Transporter
Serine/threonin kinase
Leukotriene Receptor
Glucokinase
TRP/TRPV Channel
Immunology/Inflammation related
IRE1
ABC Transporter
Monoamine Transporter
Molecular Glues
Smo
Bombesin Receptor
CXCR
cAMP
Indoleamine 2,3-Dioxygenase (IDO)
Androgen Receptor
Beta-Secretase
MNK
Acyltransferase
STING
Hippo pathway
GST
Ligand for E3 Ligase
ribosome
Phospholipase
GHSR
DAPK
PD-1/PD-L1
Kinesin
S1P Receptor
IKZF
Melanin-concentrating Hormone Receptor (MCHR)
GPCR
Adenylyl Cyclase
MicroRNA
NPC1L1
RAR/RXR
MALT
NEDD8
CRM1
Amino Acids and Derivatives
MyD88
Na+/Ca2+ Exchanger
gp120/CD4
TOPK
VDA
Melatonin Receptor
OCT
c-Myc
Hck
Cell Cycle Arrest
Liver X Receptor
Neurotensin Receptor
FXR
Glutaminase
NR4A
MAO
IDO
iGluR
Myosin
UGT
MTH1
Glucagon Receptor
P2X Receptor
Hexokinase
Guanylate cyclase
Neuropeptide Y Receptor
Fatty Acid Synthase
Thioredoxin
PAK
FAAH
Xanthine Oxidase
KSP
Thrombopoietin Receptor
ATP Citrate Lyase
Wee1
BCRP
OXPHOS
Survivin
LRRK2
Free radical scavengers
Aminopeptidase
Decarboxylase
GluCls
hCE
PAI-1
Pyroptosis
RSV
Methionine Adenosyltransferase (MAT)
CRISPR/Cas9
Adenosine Deaminase
Complement System
MDM-2/p53
Gap Junction Protein
Neurokinin receptor
Platelet aggregation
NADPH-oxidase
Sigma receptor
CFTR
PKM
Monoamine Oxidase
IGF-2R

Keywords