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PD 404182

Name: PD 404182
Brand: TargetMol
SKU: T28348
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28348Cas No. 72596-74-8

Alias PD-404182, PD404182

PD 404182 is a human dimethylarginine dimethylaminohydrolase 1 (DDAH1) inhibitor with anti-angiogenic and antiviral activities, and can be used to study cardiovascular diseases and viral infections.

PD 404182

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Purity: 99.20%

Catalog No. T28348Alias PD-404182, PD404182Cas No. 72596-74-8

PD 404182 is a human dimethylarginine dimethylaminohydrolase 1 (DDAH1) inhibitor with anti-angiogenic and antiviral activities, and can be used to study cardiovascular diseases and viral infections.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	-	In Stock
5 mg	$75	7-10 days	7-10 days
10 mg	$113	7-10 days	7-10 days
25 mg	$228	7-10 days	7-10 days
50 mg	$372	7-10 days	7-10 days
100 mg	$548	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$80	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.20%

Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	PD 404182 is a human dimethylarginine dimethylaminohydrolase 1 (DDAH1) inhibitor with anti-angiogenic and antiviral activities, and can be used to study cardiovascular diseases and viral infections.
Targets&IC50	PBMC cells (human):200 μM (CC50), DDAH1 (human):9 μM, HIV-1 (96USNG31):0.14 μM, HIV-1 (92UG029):1.18 μM
In vitro	The enzymatic activity of human DDAH1 was significantly and dose-dependently inhibited by PD 404182, with an IC50 = 9 μM. [1] PD 404182 exhibited antiviral activity toward all the viral isolates tested, with an average IC50 of 0.55 μM (IC50 range, 0.14 μM with HIV-1 96USNG31 to 1.18 μM with HIV-1 92UG029). A 48% reduction in cell viability was observed at the highest tested PD 404182 concentration (200 μM), resulting in a CC50 of ∼200 μM, indicating that PD 404182 is relatively nontoxic to freshly activated human PBMCs. [2]
Synonyms	PD-404182, PD404182

Chemical Properties

Molecular Weight	217.29
Formula	C₁₁H₁₁N₃S
Cas No.	72596-74-8
Smiles	N=C1SC=2C=CC=CC2C3=NCCCN13
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (184.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6021 mL	23.0107 mL	46.0214 mL	230.1072 mL
5 mM	0.9204 mL	4.6021 mL	9.2043 mL	46.0214 mL
10 mM	0.4602 mL	2.3011 mL	4.6021 mL	23.0107 mL
20 mM	0.2301 mL	1.1505 mL	2.3011 mL	11.5054 mL
50 mM	0.0920 mL	0.4602 mL	0.9204 mL	4.6021 mL
100 mM	0.0460 mL	0.2301 mL	0.4602 mL	2.3011 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc