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Liquiritigenin

Name: Liquiritigenin
Brand: TargetMol
SKU: T3325
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3325Cas No. 578-86-9

Alias 4',7-Dihydroxyflavanone

Liquiritigenin (4',7-Dihydroxyflavanone), a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.

Liquiritigenin

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Purity: 99.99%

Catalog No. T3325Alias 4',7-DihydroxyflavanoneCas No. 578-86-9

Liquiritigenin (4',7-Dihydroxyflavanone), a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$35	In Stock	In Stock
100 mg	$48	In Stock	In Stock
500 mg	$133	In Stock	In Stock
1 g	$196	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.99%

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Liquiritigenin AI Summary

Liquiritigenin exhibits a wide range of bioactivities across various biological systems. It demonstrates high cytotoxicity against human PANC1 cells in nutrient-deprived conditions and several other human and animal cell lines, including CEM, HL60, and MDCK cells, among others. The compound has significant inhibitory effects on LPS-induced nitric oxide production in macrophages, and it also suppresses various inflammatory cytokines and MMP enzymes in U937 cells, suggesting anti-inflammatory properties. In enzymatic assays, Liquiritigenin inhibits human aromatase with an IC50 of 2100 nM and displays potent inhibitory activity against cow milk xanthine oxidase, achieving 100% inhibition at 50 µg/mL. However, its ability to inhibit human recombinant PTP1B is relatively weak, with IC50 values greater than 60,000 nM. Additionally, Liquiritigenin shows antiviral activities, including inhibition of SARS-CoV-2 3CL-Pro protease at 25.18% and reduction of SARS-CoV-2 induced cytotoxicity in Caco-2 cells. It also exhibits antitussive and expectorant activities in mouse models and slight inhibition of human HDAC6 activity. Moreover, the compound inhibits melanin synthesis in NHEM cells and demonstrates estrogenic activity across various human cell lines, stimulating cell proliferation similarly to estradiol. Liquiritigenin also exhibits a slight antioxidant effect and inhibitory activity against both acetylcholinesterase and butyrylcholinesterase. In summary, Liquiritigenin possesses diverse pharmacological effects, including cytotoxic, anti-inflammatory, antiviral, enzymatic inhibition, estrogenic, and antihyperlipidemic activities, making it a potentially valuable compound for further drug development and therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Liquiritigenin (4',7-Dihydroxyflavanone), a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.
Targets&IC50	ERE tk-Luc:36.5 nM (EC50)
Synonyms	4',7-Dihydroxyflavanone

Chemical Properties

Molecular Weight	256.25
Formula	C₁₅H₁₂O₄
Cas No.	578-86-9
Smiles	O=C1C=2C(O[C@@H](C1)C3=CC=C(O)C=C3)=CC(O)=CC2
Relative Density.	1.386g/cm3

Storage & Solubility Information

Storage

store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (390.24 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (15.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9024 mL	19.5122 mL	39.0244 mL	195.1220 mL
5 mM	0.7805 mL	3.9024 mL	7.8049 mL	39.0244 mL
10 mM	0.3902 mL	1.9512 mL	3.9024 mL	19.5122 mL
20 mM	0.1951 mL	0.9756 mL	1.9512 mL	9.7561 mL
50 mM	0.0780 mL	0.3902 mL	0.7805 mL	3.9024 mL
100 mM	0.0390 mL	0.1951 mL	0.3902 mL	1.9512 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc