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Anti-CD146/MCAM Antibody (4Y548)
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Catalog No. TMAY-00290
Alias MUC18, melanoma cell adhesion molecule, CD146
Anti-CD146/MCAM Antibody (4Y548) is a Mouse antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody (4Y548) can be used in FCM.
Anti-CD146/MCAM Antibody (4Y548)
Anti-CD146/MCAM Antibody (4Y548)
😃Good
Catalog No. TMAY-00290Alias MUC18, melanoma cell adhesion molecule, CD146
Anti-CD146/MCAM Antibody (4Y548) is a Mouse antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody (4Y548) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-CD146/MCAM Antibody (4Y548) is a Mouse antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody (4Y548) can be used in FCM. |
| Alias | MUC18, melanoma cell adhesion molecule, CD146 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 4Y548 |
| Reactivity | Human |
| Verified Activity | Profile of anti-CD146 reactivity on HeLa cells analyzed by flow cytometry. |
| Application | FCM |
| Recommended Dose | FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD146 / MCAM (rh CD146 / MCAM; TMPY-01034; NP_006491.2; Met1-Gly559). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region, and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumors, and thus has been suggested to play an important role in tumor progression and the development of metastasis in certain human carcinomas. |
| Conjucates | Unconjugated |
| Others Formats | APC/PE |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Human CD146 / MCAM protein (TMPY-01034) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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