Shopping Cart
Remove All
Your shopping cart is currently empty
Coptisine chloride
Copy Product Info
😃Good
Catalog No. T5S0056Cas No. 6020-18-4
Alias Q-100696, NSC-119754
1. Coptisine chloride (NSC-119754) can be absorbed across intestinal epithelial cells, and completely absorbed compounds.
Coptisine chloride
Copy Product Info😃Good
Purity: 99.93%
Catalog No. T5S0056Alias Q-100696, NSC-119754Cas No. 6020-18-4
1. Coptisine chloride (NSC-119754) can be absorbed across intestinal epithelial cells, and completely absorbed compounds.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $59 | In Stock | In Stock | |
| 10 mg | $95 | In Stock | In Stock | |
| 25 mg | $197 | In Stock | In Stock | |
| 50 mg | $293 | In Stock | In Stock | |
| 100 mg | $437 | In Stock | In Stock | |
| 500 mg | $982 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $66 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.93%
Appearance:Solid
Color:White to Red
Contact us for more batch information
Product Introduction
Coptisine chloride AI Summary
Coptisine chloride exhibits bioactivity as an inhibitor of HIV1 RT with an IC50 value of less than 150.0 μg/mL. It demonstrates cytotoxic activity against human A549 and HCT15 cells with IC50 values of 23,960.0 nM and 29,070.0 nM, respectively, but not significantly against SKOV3 and SK-MEL-2 cells as their IC50 values are greater than 30,000.0 nM. Additionally, Coptisine chloride shows antiproliferative activity across various cell types, including rat and human cells, with GI50 values ranging from 3,300.0 nM to 104,940.0 nM. The compound upregulates Rgc32 and Gadd45a mRNA in rat A10 cells and Gadd45a mRNA in rat 3Y1 cells at 30 μM. Notably, it also demonstrates significant growth inhibition in a range of human tumor cell lines, including breast, renal, lung, leukemia, melanoma, ovarian, prostate, and central nervous system cells, with GI50 values spanning from 192.3 nM to 12,502.59 nM. The compound shows varying degrees of cytotoxicity against human Bel7402, A549, HCT8, and C33A cell lines, with specific growth inhibition rates and IC50 values. For rat IEC-6 cells, Coptisine chloride results in a 79.0% survival rate at 10 μM concentration and activates XBP1 transcriptional activity with a ratio of 0.78 compared to control after 48 hours..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 1. Coptisine chloride (NSC-119754) can be absorbed across intestinal epithelial cells, and completely absorbed compounds. |
| Targets&IC50 | IDO:6.3 μM. |
| Synonyms | Q-100696, NSC-119754 |
| Molecular Weight | 355.77 |
| Formula | C19H14ClNO4 |
| Cas No. | 6020-18-4 |
| Smiles | [Cl-].C1Oc2cc3CC[n+]4cc5c6OCOc6ccc5cc4-c3cc2O1 |
| Relative Density. | 1.51g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5.56 mg/mL (15.63 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
| |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Coptisine chloride | purchase Coptisine chloride | Coptisine chloride cost | order Coptisine chloride | Coptisine chloride chemical structure | Coptisine chloride formula | Coptisine chloride molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.