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(R)-Lunresertib

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Catalog No. T60886Cas No. 2719793-91-4
Alias (R)-RP-6306, (R)-RP6306

(R)-Lunresertib is the enantiomer of the PKMYT1 inhibitor RP-6306, which negatively regulates CDK1 via phosphorylation of threonine 14 and cytoplasmic sequestration. (R)-Lunresertib demonstrates single-agent antitumor efficacy in CCNE1-amplified xenograft models and shows synergistic effects with gemcitabine in CCNE1-amplified or overexpressing cell lines, providing a critical tool in cancer pharmacology and precision oncology research.

(R)-Lunresertib
Other Forms of (R)-Lunresertib:
RP-6306T608892719793-90-3
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(R)-Lunresertib

😃Good
Catalog No. T60886Alias (R)-RP-6306, (R)-RP6306Cas No. 2719793-91-4
(R)-Lunresertib is the enantiomer of the PKMYT1 inhibitor RP-6306, which negatively regulates CDK1 via phosphorylation of threonine 14 and cytoplasmic sequestration. (R)-Lunresertib demonstrates single-agent antitumor efficacy in CCNE1-amplified xenograft models and shows synergistic effects with gemcitabine in CCNE1-amplified or overexpressing cell lines, providing a critical tool in cancer pharmacology and precision oncology research.
Pack SizePriceAvailabilityQuantity
1 mg$316-8 weeks
5 mg$986-8 weeks
10 mg$1856-8 weeks
25 mg$4136-8 weeks
50 mg$6686-8 weeks
100 mg$1,0706-8 weeks
200 mg$1,4506-8 weeks
1 mL x 10 mM (in DMSO)$686-8 weeks
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Product Introduction

Bioactivity
Description
(R)-Lunresertib is the enantiomer of the PKMYT1 inhibitor RP-6306, which negatively regulates CDK1 via phosphorylation of threonine 14 and cytoplasmic sequestration. (R)-Lunresertib demonstrates single-agent antitumor efficacy in CCNE1-amplified xenograft models and shows synergistic effects with gemcitabine in CCNE1-amplified or overexpressing cell lines, providing a critical tool in cancer pharmacology and precision oncology research.
Targets&IC50
PKMYT1:1360 nM
Synonyms(R)-RP-6306, (R)-RP6306
Chemical Properties
Molecular Weight324.38
FormulaC18H20N4O2
Cas No.2719793-91-4
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (246.62 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0828 mL15.4140 mL30.8280 mL154.1402 mL
5 mM0.6166 mL3.0828 mL6.1656 mL30.8280 mL
10 mM0.3083 mL1.5414 mL3.0828 mL15.4140 mL
20 mM0.1541 mL0.7707 mL1.5414 mL7.7070 mL
50 mM0.0617 mL0.3083 mL0.6166 mL3.0828 mL
100 mM0.0308 mL0.1541 mL0.3083 mL1.5414 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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