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Isolongifolene

🥰Excellent
Catalog No. T11685Cas No. 1135-66-6
Alias (-)-Isolongifolene

Isolongifolene ((-)-Isolongifolene), a tricyclic sesquiterpene isolated from Murraya koenigii, exhibits antioxidant, anti-inflammatory, anticancer, and neuroprotective properties. It mitigates Rotenone-induced oxidative stress, mitochondrial dysfunction, and apoptosis by modulating the PI3K/AKT/GSK-3β signaling pathways.

Isolongifolene

Isolongifolene

🥰Excellent
Purity: 99.46%
Catalog No. T11685Alias (-)-IsolongifoleneCas No. 1135-66-6
Isolongifolene ((-)-Isolongifolene), a tricyclic sesquiterpene isolated from Murraya koenigii, exhibits antioxidant, anti-inflammatory, anticancer, and neuroprotective properties. It mitigates Rotenone-induced oxidative stress, mitochondrial dysfunction, and apoptosis by modulating the PI3K/AKT/GSK-3β signaling pathways.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$42In StockIn Stock
2 mg$59-In Stock
5 mg$98In StockIn Stock
10 mg$156-In Stock
25 mg$263-In Stock
1 mL x 10 mM (in DMSO)$108-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.46%
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Product Introduction

Bioactivity
Description
Isolongifolene ((-)-Isolongifolene), a tricyclic sesquiterpene isolated from Murraya koenigii, exhibits antioxidant, anti-inflammatory, anticancer, and neuroprotective properties. It mitigates Rotenone-induced oxidative stress, mitochondrial dysfunction, and apoptosis by modulating the PI3K/AKT/GSK-3β signaling pathways.
In vitro
isolongifolene (ILF), a tricyclic sesquiterpene of Murraya koenigii, against rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis in a cellular model.
Synonyms(-)-Isolongifolene
Chemical Properties
Molecular Weight204.35
FormulaC15H24
Cas No.1135-66-6
Smiles[H][C@]12CC[C@]3(C1)C(=CCCC3(C)C)C2(C)C
Relative Density.0.930 g/cm3 at 20℃ (lit.)
ColorTransparent
AppearanceLiquid
Storage & Solubility Information
Storagestore under nitrogen,store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 25 mg/mL (122.34 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.8936 mL24.4678 mL48.9356 mL244.6782 mL
5 mM0.9787 mL4.8936 mL9.7871 mL48.9356 mL
10 mM0.4894 mL2.4468 mL4.8936 mL24.4678 mL
20 mM0.2447 mL1.2234 mL2.4468 mL12.2339 mL
50 mM0.0979 mL0.4894 mL0.9787 mL4.8936 mL
100 mM0.0489 mL0.2447 mL0.4894 mL2.4468 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

TricyclicsesquiterpeneRotenoneROSmitochondrialIsolongifoleneInhibitorinhibitdysfunctioncytotoxicityApoptosisantioxidantanti-inflammatoryanticancer
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