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GSK-3 Inhibitor XIII

Name: GSK-3 Inhibitor XIII
Brand: TargetMol
SKU: T78578
Price: 108 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78578Cas No. 404828-14-4

GSK-3 Inhibitor XIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.

GSK-3 Inhibitor XIII

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Purity: 99.86%

Catalog No. T78578Cas No. 404828-14-4

GSK-3 Inhibitor XIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$108	In Stock	In Stock
5 mg	$255	In Stock	In Stock
10 mg	$459	In Stock	In Stock
25 mg	$983	In Stock	In Stock
50 mg	$1,350	In Stock	In Stock
100 mg	$1,820	In Stock	In Stock
200 mg	$2,460	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$265	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

GSK-3 Inhibitor XIII AI Summary

GSK-3 Inhibitor XIII is a potent inhibitor of Glycogen synthase kinase-3, Aurora A kinase, and Src with Ki values of 24.0 nM, 58.0 nM, and 81.0 nM, respectively. It stabilizes a wide array of kinases, including AMPKA2, CAMK1D, CAMK2A, ERK1, and VRK3, indicating extensive potential interactions and modulation. GSK-3 Inhibitor XIII also exhibits significant antiproliferative activity against human COLO205 cells with an IC50 value of 1400.0 nM and various other human cancer cell lines with IC50 values ranging from 883.0 nM to 7990.0 nM, suggesting potential therapeutic applications. Additionally, it inhibits human recombinant PKR autophosphorylation with an IC50 value of 15000.0 nM, highlighting its potential as a PKR inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

GSK-3 Inhibitor XIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.

Chemical Properties

Molecular Weight	301.35
Formula	C₁₈H₁₅N₅
Cas No.	404828-14-4
Smiles	N=1NC(=CC1NC=2N=C(N=C3C=CC=CC32)C=4C=CC=CC4)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (265.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.95 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3184 mL	16.5920 mL	33.1840 mL	165.9200 mL
5 mM	0.6637 mL	3.3184 mL	6.6368 mL	33.1840 mL
10 mM	0.3318 mL	1.6592 mL	3.3184 mL	16.5920 mL
20 mM	0.1659 mL	0.8296 mL	1.6592 mL	8.2960 mL
50 mM	0.0664 mL	0.3318 mL	0.6637 mL	3.3184 mL
100 mM	0.0332 mL	0.1659 mL	0.3318 mL	1.6592 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc