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Oxothiazolidinecarboxylic acid

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Catalog No. T5365Cas No. 19771-63-2
Alias Procysteine, Oxothiazolidine carboxylate

Oxothiazolidinecarboxylic acid (Procysteine) is a precursor to glutathione (GSH) which is an important antioxidant in plants, animals, and fungi.

Oxothiazolidinecarboxylic acid

Oxothiazolidinecarboxylic acid

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Purity: 98.8%
Catalog No. T5365Alias Procysteine, Oxothiazolidine carboxylateCas No. 19771-63-2
Oxothiazolidinecarboxylic acid (Procysteine) is a precursor to glutathione (GSH) which is an important antioxidant in plants, animals, and fungi.
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1 g$29-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.8%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Oxothiazolidinecarboxylic acid (Procysteine) is a precursor to glutathione (GSH) which is an important antioxidant in plants, animals, and fungi.
In vivo
Procysteine stimulated gene expression of anabolic factors such as insulin-like growth factor-1, ciliary neurotrophic factor, and cardiotrophin-1[2]. Procysteine supplementation eliminated the aging-associated differences in hepatic GSH and GSH/GSSG ratio. The nSMase activity and ceramide increased in the procysteine-fed mice irrespective of their age. The procysteine-fed aged mice also exhibited hepatic steatosis and triacylglyceride accumulation [3].
SynonymsProcysteine, Oxothiazolidine carboxylate
Chemical Properties
Molecular Weight147.15
FormulaC4H5NO3S
Cas No.19771-63-2
SmilesOC(=O)[C@@H]1CSC(=O)N1
Relative Density.1.582 g/cm3
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (373.77 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (13.59 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM6.7958 mL33.9789 mL67.9579 mL339.7893 mL
5 mM1.3592 mL6.7958 mL13.5916 mL67.9579 mL
10 mM0.6796 mL3.3979 mL6.7958 mL33.9789 mL
20 mM0.3398 mL1.6989 mL3.3979 mL16.9895 mL
50 mM0.1359 mL0.6796 mL1.3592 mL6.7958 mL
100 mM0.0680 mL0.3398 mL0.6796 mL3.3979 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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