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Tubulin inhibitor 35

🥰Excellent
Catalog No. T77584Cas No. 2247047-77-2
Alias Tubulin IN 35

Tubulin inhibitor 35 (Tubulin IN 35) is a potent dual inhibitor of topoisomerase I and microtubule protein polymerization with antitumor activity, inhibits migration and invasion of MGC-803 and RKO cell lines, interrupts the cell cycle and induces apoptosis.

Tubulin inhibitor 35

Tubulin inhibitor 35

🥰Excellent
Purity: 99.45%
Catalog No. T77584Alias Tubulin IN 35Cas No. 2247047-77-2
Tubulin inhibitor 35 (Tubulin IN 35) is a potent dual inhibitor of topoisomerase I and microtubule protein polymerization with antitumor activity, inhibits migration and invasion of MGC-803 and RKO cell lines, interrupts the cell cycle and induces apoptosis.
Pack SizePriceAvailabilityQuantity
1 mg$54In Stock
5 mg$126In Stock
10 mg$185In Stock
25 mg$297In Stock
50 mg$458In Stock
100 mg$668In Stock
500 mg$2,350In Stock
1 g$3,230In Stock
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Purity:99.45%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
Tubulin inhibitor 35 (Tubulin IN 35) is a potent dual inhibitor of topoisomerase I and microtubule protein polymerization with antitumor activity, inhibits migration and invasion of MGC-803 and RKO cell lines, interrupts the cell cycle and induces apoptosis.
SynonymsTubulin IN 35
Chemical Properties
Molecular Weight331.41
FormulaC21H21N3O
Cas No.2247047-77-2
SmilesO=C1C=2C=CC=CC2N(CCC)C3C=4NC=5C=CC=CC5C4CCN13
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (150.87 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0174 mL15.0871 mL30.1741 mL150.8705 mL
5 mM0.6035 mL3.0174 mL6.0348 mL30.1741 mL
10 mM0.3017 mL1.5087 mL3.0174 mL15.0871 mL
20 mM0.1509 mL0.7544 mL1.5087 mL7.5435 mL
50 mM0.0603 mL0.3017 mL0.6035 mL3.0174 mL
100 mM0.0302 mL0.1509 mL0.3017 mL1.5087 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Tubulininhibitor35Tubulintopoisomerase IMicrotubuleAssociatedMicrotubule AssociatedApoptosis
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