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N-Methylcytisine

🥰Excellent
Catalog No. T5S0994Cas No. 486-86-2
Alias Caulophylline

1. N-Methylcytisine (Caulophylline)'s nicotinic receptors have high affinity (KD = 5 nM)to nAChR from squid optical ganglia. 2. N-Methylcytisine and N, N-dimethylcytisine did not displace 14C-tubocurarine at a concentration of .1 mM, cytisine was the only effective inhibitor of 14C-tubocurarine specific binding (Ki=7 nM).

N-Methylcytisine

N-Methylcytisine

🥰Excellent
Purity: 99.89%
Catalog No. T5S0994Alias CaulophyllineCas No. 486-86-2
1. N-Methylcytisine (Caulophylline)'s nicotinic receptors have high affinity (KD = 5 nM)to nAChR from squid optical ganglia. 2. N-Methylcytisine and N, N-dimethylcytisine did not displace 14C-tubocurarine at a concentration of .1 mM, cytisine was the only effective inhibitor of 14C-tubocurarine specific binding (Ki=7 nM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$30In StockIn Stock
5 mg$48In StockIn Stock
10 mg$77In StockIn Stock
25 mg$147In StockIn Stock
50 mg$239In StockIn Stock
100 mg$355-In Stock
1 mL x 10 mM (in DMSO)$53In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.89%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
1. N-Methylcytisine (Caulophylline)'s nicotinic receptors have high affinity (KD = 5 nM)to nAChR from squid optical ganglia. 2. N-Methylcytisine and N, N-dimethylcytisine did not displace 14C-tubocurarine at a concentration of .1 mM, cytisine was the only effective inhibitor of 14C-tubocurarine specific binding (Ki=7 nM).
Targets&IC50
14C-tubocurarine:7 nM(Ki)
SynonymsCaulophylline
Chemical Properties
Molecular Weight204.27
FormulaC12H16N2O
Cas No.486-86-2
SmilesCN1C[C@@H]2C[C@H](C1)c1cccc(=O)n1C2
Relative Density.1.21g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 27.5 mg/mL (134.63 mM), Sonication is recommended.
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.79 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.8955 mL24.4774 mL48.9548 mL244.7741 mL
5 mM0.9791 mL4.8955 mL9.7910 mL48.9548 mL
10 mM0.4895 mL2.4477 mL4.8955 mL24.4774 mL
20 mM0.2448 mL1.2239 mL2.4477 mL12.2387 mL
50 mM0.0979 mL0.4895 mL0.9791 mL4.8955 mL
100 mM0.0490 mL0.2448 mL0.4895 mL2.4477 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

N-MethylcytisineNMethylcytisineNicotinic acetylcholine receptorsnAChRN MethylcytisineInhibitorinhibit
Related Tags: buy N-Methylcytisine | purchase N-Methylcytisine | N-Methylcytisine cost | order N-Methylcytisine | N-Methylcytisine chemical structure | N-Methylcytisine formula | N-Methylcytisine molecular weight
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