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Protein kinase inhibitor 6

Name: Protein kinase inhibitor 6
Brand: TargetMol
SKU: T9779
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T9779 Copy Product Info

Purity: 98.01%

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Protein kinase inhibitor 6 (PKI 6) is a compound that acts as an inhibitor of protein kinases.

Protein kinase inhibitor 6

Copy Product Info

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Catalog No. T9779

Protein kinase inhibitor 6 (PKI 6) is a compound that acts as an inhibitor of protein kinases.

Cas No. 348-45-8

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Pack Size	Price	USA Stock	Global Stock
2 mg	$30	In Stock	In Stock
5 mg	$50	In Stock	In Stock
10 mg	$83	In Stock	In Stock
25 mg	$175	In Stock	In Stock
50 mg	$247	In Stock	In Stock
100 mg	$359	In Stock	In Stock
200 mg	$489	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.01%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Protein kinase inhibitor 6 AI Summary

Protein kinase inhibitor 6 exhibits various bioactivities, including modulation of miRNAs, activation of miR-21, Rab9 promotion, SMN2 splice variant enhancement, and NPC1 promotion. It inhibits miR-21, Nrf2, miR-21, ELG1-dependent DNA repair, malarial parasite plastids, Polymerase Iota, and TDP-43. Additionally, it acts on firefly luciferase as an inhibitor or activator and inhibits Marburg Virus entry into cells. It is also involved in inducing DNA re-replication in normal breast and colon adenocarcinoma cells, genotoxicity in human embryonic kidney cells, and screening antivirals against Foot and Mouth Disease Virus..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Protein kinase inhibitor 6 (PKI 6) is a compound that acts as an inhibitor of protein kinases.

Chemical Properties

Molecular Weight	244.29
Formula	C₁₃H₉FN₂S
Cas No.	348-45-8
Smiles	N(C1=NC=2C(S1)=CC=CC2)C3=CC=C(F)C=C3
Relative Density.	1.384g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (225.14 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0935 mL	20.4675 mL	40.9350 mL	204.6748 mL
5 mM	0.8187 mL	4.0935 mL	8.1870 mL	40.9350 mL
10 mM	0.4093 mL	2.0467 mL	4.0935 mL	20.4675 mL
20 mM	0.2047 mL	1.0234 mL	2.0467 mL	10.2337 mL
50 mM	0.0819 mL	0.4093 mL	0.8187 mL	4.0935 mL
100 mM	0.0409 mL	0.2047 mL	0.4093 mL	2.0467 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc