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E3 ligase Ligand 23

Name: E3 ligase Ligand 23
Brand: TargetMol
SKU: T9809
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9809Cas No. 444287-56-3

E3 ligase Ligand 23 is a cereblon binding agent that degrades Ikaros or Aiolos via the ubiquitin proteasome.

E3 ligase Ligand 23

🥰Excellent

Purity: 98.49%

Catalog No. T9809Cas No. 444287-56-3

E3 ligase Ligand 23 is a cereblon binding agent that degrades Ikaros or Aiolos via the ubiquitin proteasome.

Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$48	In Stock
10 mg	$76	In Stock
25 mg	$153	In Stock
50 mg	$248	In Stock
100 mg	$353	In Stock
200 mg	$480	In Stock
1 mL x 10 mM (in DMSO)	$66	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.49%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description

E3 ligase Ligand 23 is a cereblon binding agent that degrades Ikaros or Aiolos via the ubiquitin proteasome.

Chemical Properties

Molecular Weight	363.37
Formula	C₂₀H₁₇N₃O₄
Cas No.	444287-56-3
Smiles	N(CC1=CC=CC=C1)C2=C3C(C(=O)N(C3=O)C4C(=O)NC(=O)CC4)=CC=C2
Relative Density.	1.442 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (151.36 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7520 mL	13.7601 mL	27.5202 mL	137.6008 mL
5 mM	0.5504 mL	2.7520 mL	5.5040 mL	27.5202 mL
10 mM	0.2752 mL	1.3760 mL	2.7520 mL	13.7601 mL
20 mM	0.1376 mL	0.6880 mL	1.3760 mL	6.8800 mL
50 mM	0.0550 mL	0.2752 mL	0.5504 mL	2.7520 mL
100 mM	0.0275 mL	0.1376 mL	0.2752 mL	1.3760 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc