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4-Hydroxyacetophenone

Name: 4-Hydroxyacetophenone
Brand: TargetMol
SKU: T3750
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3750Cas No. 99-93-4

Alias Piceol, p-Acetylphenol, 4'-Hydroxyacetophenone, 4-Acetylphenol

4-Hydroxyacetophenone (4-Acetylphenol) is a potent xanthine oxidase inhibitor.

4-Hydroxyacetophenone

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Purity: 99.94%

Catalog No. T3750Alias Piceol, p-Acetylphenol, 4'-Hydroxyacetophenone, 4-AcetylphenolCas No. 99-93-4

4-Hydroxyacetophenone (4-Acetylphenol) is a potent xanthine oxidase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$41	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.94%

Appearance:Solid

Color:White

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COA HNMR LCMS HPLC

Product Introduction

4-Hydroxyacetophenone AI Summary

4-Hydroxyacetophenone demonstrates a range of bioactivities across various biological targets. It inhibits succinic semialdehyde dehydrogenase (SSADH) with an IC50 of 166,000 nM and gamma-aminobutyric acid transaminase (GABAT) with an IC50 of 188,000 nM. It also exhibits inhibition of the enzyme 17beta-HSD3, showing an IC50 value of 1,708,920 nM and 36.59% inhibition at a 100 µM concentration. Additionally, 4-Hydroxyacetophenone shows activity in caspase-mediated apoptosis in mouse L1210 cells, with a log(1/ID50) value of 0.03 and less than 15% activity at 0.1 mM concentration. Binding affinity studies indicate a log Ks value of 2.18 for beta cyclodextrin. The compound displays antitubercular activity against Mycobacterium tuberculosis H37Rv with a MIC of 121 µg/mL and exhibits bioactivity in expressed human recombinant enzymes UGT1A6 and UGT1A9. Its antifungal activity against Alternaria alternata shows a maximum of 50% inhibition at 100 µM concentration. In plant physiology, it inhibits H+ uptake in spinach chloroplasts, mitochondrial respiration in Phaseolus vulgaris roots, and seed respiration in several plant species, impacting germination and seedling development. It also binds to Enterobacteria phage T4 lysozyme L99A/M102H mutant, altering the melting temperature by 0.5 degrees Celsius at 1 mM concentration. 4-Hydroxyacetophenone has antiviral efficacy against hepatitis B in HepG2.2.15 cells, reducing HBsAg and HBeAg secretion and inhibiting viral DNA replication, though it also shows cytotoxicity in these cells. Despite its antineuroinflammatory potential in inhibiting nitric oxide production in mouse N9 cells, the IC50 is greater than 100,000 nM, suggesting weak activity. Moreover, it functions as a substrate for multiple alcohol dehydrogenase enzymes, with activity measured via UV-Vis spectroscopy in nmol/min/mg under various conditions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	4-Hydroxyacetophenone (4-Acetylphenol) is a potent xanthine oxidase inhibitor.
Synonyms	Piceol, p-Acetylphenol, 4'-Hydroxyacetophenone, 4-Acetylphenol

Chemical Properties

Molecular Weight	136.15
Formula	C₈H₈O₂
Cas No.	99-93-4
Smiles	CC(=O)C1=CC=C(O)C=C1
Relative Density.	1.109 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (403.97 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (14.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.3448 mL	36.7242 mL	73.4484 mL	367.2420 mL
5 mM	1.4690 mL	7.3448 mL	14.6897 mL	73.4484 mL
10 mM	0.7345 mL	3.6724 mL	7.3448 mL	36.7242 mL
20 mM	0.3672 mL	1.8362 mL	3.6724 mL	18.3621 mL
50 mM	0.1469 mL	0.7345 mL	1.4690 mL	7.3448 mL
100 mM	0.0734 mL	0.3672 mL	0.7345 mL	3.6724 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc