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Moroxydine hydrochloride

Name: Moroxydine hydrochloride
Brand: TargetMol
SKU: T0090
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0090Cas No. 3160-91-6

Alias Moroxydine HCl, ABOB hydrochloride

Moroxydine hydrochloride (ABOB hydrochloride) is a synthetic antiviral drug chemically belonging to the series of the heterocyclic biguanidines. It has antiviral activity and is helpful in the prevention and treatment of influenza.

Moroxydine hydrochloride

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Purity: 99.15%

Catalog No. T0090Alias Moroxydine HCl, ABOB hydrochlorideCas No. 3160-91-6

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$31	In Stock	In Stock
1 g	$38	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.15%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Moroxydine hydrochloride AI Summary

Moroxydine hydrochloride has demonstrated various bioactivities in different biological contexts. It shows a potency of 9285.0 nM as an inhibitor of delayed death in the malarial parasite plastid. In SW480 colon adenocarcinoma cells, it induces DNA re-replication with a potency of 794.3 nM. It also acts as a TDP-43 inhibitor with a potency of 28183.8 nM. In the context of Ebola Virus entry inhibition, Moroxydine hydrochloride has an AC50 of 1.413 μM in the blue channel and 0.631 μM in the ratio channel. Regarding its antiviral properties, Moroxydine hydrochloride exhibits activity against SARS-CoV-2. Specifically, it shows low-level inhibition of cell viability in Vero E6 cells infected with SARS-CoV-2 strain BavPat1, with an inhibition index of 0.171. It inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by -6.4% at a 10 μM concentration after 48 hours, and it shows 11.42% inhibition of SARS-CoV-2 3CL-Pro protease at a 20 μM concentration. Additionally, it demonstrates -0.02% inhibition of SARS-CoV-2 induced cytotoxicity in VERO-6 cells under similar conditions. Furthermore, Moroxydine hydrochloride exhibits high solubility at pH 8, with a value of 360000.0 μg/mL. It also shows a binding affinity to SARS-CoV-2 3CL protease, with a Gibbs free energy change of -2.11 kcal/mol, indicating its potential as a protease inhibitor in the treatment of SARS-CoV-2 infections..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Moroxydine hydrochloride (ABOB hydrochloride) is a synthetic antiviral drug chemically belonging to the series of the heterocyclic biguanidines. It has antiviral activity and is helpful in the prevention and treatment of influenza.
Synonyms	Moroxydine HCl, ABOB hydrochloride

Chemical Properties

Molecular Weight	207.66
Formula	C₆H₁₃N₅O·HCl
Cas No.	3160-91-6
Smiles	Cl.NC(=N)NC(=N)N1CCOCC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (240.78 mM), Sonication is recommended.

H2O: 202.3 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8156 mL	24.0778 mL	48.1556 mL	240.7782 mL
5 mM	0.9631 mL	4.8156 mL	9.6311 mL	48.1556 mL
10 mM	0.4816 mL	2.4078 mL	4.8156 mL	24.0778 mL
20 mM	0.2408 mL	1.2039 mL	2.4078 mL	12.0389 mL
50 mM	0.0963 mL	0.4816 mL	0.9631 mL	4.8156 mL
100 mM	0.0482 mL	0.2408 mL	0.4816 mL	2.4078 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc