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Anti-Phospho-ATR (Ser428) Polyclonal Antibody
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Catalog No. TMAC-00343
Alias p-ATR (Ser428), p-ATR (S428), ATR (p-Ser428), ATR (p-S428)
Anti-Phospho-ATR (Ser428) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ATR (Ser428). Anti-Phospho-ATR (Ser428) Polyclonal Antibody can be used in IHC,IF.
Anti-Phospho-ATR (Ser428) Polyclonal Antibody
Anti-Phospho-ATR (Ser428) Polyclonal Antibody
😃Good
Catalog No. TMAC-00343Alias p-ATR (Ser428), p-ATR (S428), ATR (p-Ser428), ATR (p-S428)
Anti-Phospho-ATR (Ser428) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ATR (Ser428). Anti-Phospho-ATR (Ser428) Polyclonal Antibody can be used in IHC,IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $216 | 7-10 days | |
| 100 μL | $318 | 7-10 days |
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| Description | Anti-Phospho-ATR (Ser428) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ATR (Ser428). Anti-Phospho-ATR (Ser428) Polyclonal Antibody can be used in IHC,IF. |
| Synonyms | p-ATR (Ser428), p-ATR (S428), ATR (p-Ser428), ATR (p-S428) |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using ATR (Phospho-Ser428) antibody TMAC-00343. The picture on the right is treated with the synthesized peptide. |
| Application | |
| Recommended Dose | IHC: 1:100-300; IF: 1:50-200 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Appearance | Liquid |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Research Background | Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | A synthesized phosphopeptide: human ATR around the phosphorylation site of Ser428 |
| Antigen Species | human |
| Uniprot ID |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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