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TargetMol | Compound Library

Anti-Gram-Negative Bacterial Library

Catalog No. L4521

Gram-negative bacteria are a class of bacteria that appear red or pink in Gram staining. They possess a complex cell structure characterized by a thin peptidoglycan layer and a crucial outer membrane. This outer membrane contains lipopolysaccharides (LPS, also known as endotoxins), which not only enhance their environmental adaptability but also significantly contribute to their intrinsic resistance to antibiotics. Common pathogenic Gram-negative bacteria include Escherichia coli, Helicobacter pylori, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella spp. These pathogens are major causes of urinary tract infections, gastric cancer, pneumonia, intra-abdominal infections, and hospital-acquired infections.
In recent years, the rapid spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative bacteria has become a major challenge in clinical treatment. Particularly concerning are strains that produce extended-spectrum β-lactamases (ESBLs) and carbapenemases (such as NDM and KPC), which confer resistance to a broad range of β-lactam antibiotics, including penicillins, cephalosporins, and carbapenems. These strains often also show cross-resistance to aminoglycosides and fluoroquinolones, leaving very limited treatment options and highlighting the urgent need for the development of novel and effective antimicrobial agents.
TargetMol’s Anti-Gram-Negative Bacteria Compound Library includes 240 small molecules with activity against Gram-negative bacteria. It serves as a powerful tool for antibacterial drug research.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L4521

Anti-Gram-Negative Bacterial Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • Contains 240 types of compounds with activity against Gram-negative bacteria, suitable for high-throughput and high-content screening;
  • A powerful tool for antimicrobial drug research;
  • Rich documentation with structure, target, IC50 value and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity.

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Library Customization | TargetMol Library Composition

Antibacterial
Antibiotic
Autophagy
Topoisomerase
Endogenous Metabolite
Antifungal
Apoptosis
Parasite
ribosome
DNA/RNA Synthesis
Antifection
DNA gyrase
HIV Protease
Cytochromes P450
Ferroptosis
Anti-infection
Dehydrogenase
DHFR
NF-κB
Reactive Oxygen Species
STAT
Carbonic Anhydrase
Cell wall
COX
Estrogen Receptor/ERR
Estrogen/progestogen Receptor
Glucokinase
HSV
Mitophagy
Phospholipase
PI3K
Potassium Channel
PPAR
Proton pump
ROS
TNF
5-HT Receptor
Acetyl-CoA Carboxylase
Akt
Amylase
Antifolate
Antioxidant
Aromatase
Bcr-Abl
Casein Kinase
CDK
Chloride channel
CRISPR/Cas9
DNA Methyltransferase
Dopamine Receptor
Drug Metabolite
Endothelin Receptor
Fatty Acid Synthase
Gamma-secretase
Glucosidase
Glutathione Peroxidase
Glutathione reductase
Hedgehog/Smoothened
Histamine Receptor
HSP
Influenza Virus
Liver X Receptor
MicroRNA
MMP
MRP
NADPH
NOD-like Receptor (NLR)
NOS
Nrf2
p38 MAPK
PD-1/PD-L1
PKA
PKC
PKM
Reverse Transcriptase
Sirtuin
Src
Syk
Telomerase
TGF-beta/Smad
TOPK
TRP/TRPV Channel
Virus Protease
Xanthine Oxidase