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TargetMol | Compound Library

Anti-Gram-Negative Bacterial Library

Catalog No. L4521

Gram-negative bacteria are a class of bacteria that appear red or pink in Gram staining. They possess a complex cell structure characterized by a thin peptidoglycan layer and a crucial outer membrane. This outer membrane contains lipopolysaccharides (LPS, also known as endotoxins), which not only enhance their environmental adaptability but also significantly contribute to their intrinsic resistance to antibiotics. Common pathogenic Gram-negative bacteria include Escherichia coli, Helicobacter pylori, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella spp. These pathogens are major causes of urinary tract infections, gastric cancer, pneumonia, intra-abdominal infections, and hospital-acquired infections.
In recent years, the rapid spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative bacteria has become a major challenge in clinical treatment. Particularly concerning are strains that produce extended-spectrum β-lactamases (ESBLs) and carbapenemases (such as NDM and KPC), which confer resistance to a broad range of β-lactam antibiotics, including penicillins, cephalosporins, and carbapenems. These strains often also show cross-resistance to aminoglycosides and fluoroquinolones, leaving very limited treatment options and highlighting the urgent need for the development of novel and effective antimicrobial agents.
TargetMol’s Anti-Gram-Negative Bacteria Compound Library includes undefined small molecules with activity against Gram-negative bacteria. It serves as a powerful tool for antibacterial drug research.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L4521

Anti-Gram-Negative Bacterial Library

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Product Description Product Description

  • Contains undefined types of compounds with activity against Gram-negative bacteria, suitable for high-throughput and high-content screening;
  • A powerful tool for antimicrobial drug research;
  • Rich documentation with structure, target, IC50 value and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity.

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Library Customization | TargetMol Library Composition

Antibacterial
Antibiotic
Autophagy
Topoisomerase
Endogenous Metabolite
Antifungal
Apoptosis
Parasite
ribosome
DNA/RNA Synthesis
Antifection
DNA gyrase
HIV Protease
Cytochromes P450
Ferroptosis
DHFR
Reactive Oxygen Species
STAT
Anti-infection
NF-κB
Dehydrogenase
Mitophagy
Cell wall
PI3K
COX
HSV
TNF
Proton pump
Potassium Channel
Phospholipase
Carbonic Anhydrase
Estrogen/progestogen Receptor
Glucokinase
ROS
Estrogen Receptor/ERR
PPAR
Glutathione Peroxidase
PKA
Chloride channel
Syk
Nrf2
Acetyl-CoA Carboxylase
Amylase
HSP
DNA Methyltransferase
PKC
Aromatase
Gamma-secretase
Bcr-Abl
Glutathione reductase
TRP/TRPV Channel
Telomerase
Histamine Receptor
MRP
Endothelin Receptor
PKM
Drug Metabolite
NOS
MMP
Casein Kinase
Akt
CRISPR/Cas9
NOD-like Receptor (NLR)
CDK
5-HT Receptor
TOPK
Src
Influenza Virus
TGF-beta/Smad
Antioxidant
PD-1/PD-L1
Antifolate
MicroRNA
Fatty Acid Synthase
Reverse Transcriptase
p38 MAPK
Virus Protease
Sirtuin
Glucosidase
Hedgehog/Smoothened
NADPH
Liver X Receptor
Xanthine Oxidase
Dopamine Receptor