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Thiobarbituric acid

Name: Thiobarbituric acid
Brand: TargetMol
SKU: T20550
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20550Cas No. 504-17-6

Alias NSC-4733, NSC4733, NSC 4733

Thiobarbituric acid (NSC-4733) has Antibacterial Activity.

Thiobarbituric acid

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Purity: 99.71%

Catalog No. T20550Alias NSC-4733, NSC4733, NSC 4733Cas No. 504-17-6

Thiobarbituric acid (NSC-4733) has Antibacterial Activity.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$34	In Stock	In Stock
100 mg	$56	In Stock	In Stock
500 mg	$133	In Stock	In Stock
1 g	$198	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.71%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Thiobarbituric acid AI Summary

Thiobarbituric acid exhibits inhibitory activity against mushroom tyrosinase, with an IC50 value greater than 200,000 nM. At a concentration of 200 µM, it shows 8.21% inhibition of mushroom tyrosinase. When tested at 100 µM with preincubation for 10 minutes using L-DOPA as a substrate, it demonstrated less than 20% inhibition of mushroom tyrosinase diphenolase activity compared to the control. Additionally, Thiobarbituric acid shows activity at the human TAS2R38 receptor expressed in HEK-293T-Galpha16-gustducin44 cells, as measured by a FLIPR assay with an activity concentration of 10.0 mM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Thiobarbituric acid (NSC-4733) has Antibacterial Activity.
Synonyms	NSC-4733, NSC4733, NSC 4733

Chemical Properties

Molecular Weight	144.15
Formula	C₄H₄N₂O₂S
Cas No.	504-17-6
Smiles	O=C1CC(=O)NC(=S)N1
Relative Density.	1.451 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (381.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.9372 mL	34.6861 mL	69.3722 mL	346.8609 mL
5 mM	1.3874 mL	6.9372 mL	13.8744 mL	69.3722 mL
10 mM	0.6937 mL	3.4686 mL	6.9372 mL	34.6861 mL
20 mM	0.3469 mL	1.7343 mL	3.4686 mL	17.3430 mL
50 mM	0.1387 mL	0.6937 mL	1.3874 mL	6.9372 mL
100 mM	0.0694 mL	0.3469 mL	0.6937 mL	3.4686 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc