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TargetMol | Compound Library

Anti-COVID-19 Compound Library

Catalog No. L1710

In response to the outbreak of COVID-19 caused by a novel coronavirus SARS-CoV-2, global scientific research institutions and pharmaceutical companies are stepping up related vaccine development and antiviral drug trials. Scientists from multiple countries are working hard to identify drug candidates that can be used for clinical therapy to patients with COVID-19 by screening compound libraries. TargetMol as a drug screening expert quickly generated this compound library to support the research and development of anti-COVID-19 drugs. This compound library includes Part1 and Part2. Part1 contains compounds that have been demonstrated to have anti-coronavirus activity or are broad-spectrum antiviral agents including Remdesivir, Lopinavir/Ritonavir, Chloroquine diphosphate (combination use with Remdesivir), Polydatin (bind with Mpro), etc. Part2 collects compounds from virtual screening hits based on molecular docking. These compounds with high-affinity to 7 SARS-CoV-2 protein targets (RBD of Spike protein, viral papain like protease (PLpro), main protease (3CLpro, also named 3-chymotrypsin-like protease), RNA-dependent RNA polymerase (RdRp), nsp16 (2′-O-methyltransferase, helicase), nsp15, and X-domain.) and 1 human ACE2 have the potential to provide more drug candidates for molecular and cellular antiviral activity assays. As a world-renowned supplier of small molecular compounds, TargetMol immediately after the outbreak of COVID-19 performed a Swiss-Model Homology Modelling process to generate reliable protein models or 3D protein structures of these related drug targets. Then structure-based virtual screening was performed against TargetMol libraries (7729 compounds) and Bioactive compound library (7647 compounds) by using Surflex-Dock in the Sybyl-X 2.0 package. Having anti-COVID-19 CADD activity from virtual screening formed Part2 of this compound library. We wish these compounds would speed up the development of COVID-19 targeted drugs. We also will keep updating it in response to the newest research progress.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L1710

Anti-COVID-19 Compound Library
sizeIn stock
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 1133 compounds with confirmed anti-SARS-CoV-2 activity or potential activity and part of them are broad-spectrum antiviral agents;
  • Compounds contain Remdesivir, Lopinavir/Ritonavir, Chloroquine diphosphate (combination use with Remdesivir), Polydatin (bind with Mpro), etc.;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

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Library Customization | TargetMol Library Composition

Autophagy
Endogenous Metabolite
Apoptosis
Antibacterial
HIV Protease
Antibiotic
DNA/RNA Synthesis
Influenza Virus
HCV Protease
Parasite
Reactive Oxygen Species
SARS-CoV
Reverse Transcriptase
HBV
Calcium Channel
Potassium Channel
Adrenergic Receptor
HSV
Antifungal
5-HT Receptor
RAAS
COX
NF-κB
P450
Ferroptosis
PI3K
Antioxidant
Histamine Receptor
Nucleoside Antimetabolite/Analog
AChR
Mitophagy
VEGFR
Dopamine Receptor
Histone Methyltransferase
Dehydrogenase
Virus Protease
Antiviral
Prostaglandin Receptor
PDE
Antifection
c-Kit
CCR
Epigenetic Reader Domain
Sodium Channel
PKC
Topoisomerase
PDGFR
EGFR
TNF
FLT
HDAC
Proteasome
PPAR
CDK
mTOR
Phosphatase
JAK
Akt
ribosome
Src
Adenosine Receptor
Caspase
TLR
AMPK
c-Met/HGFR
Raf
STAT
FGFR
Transferase
Integrin
Estrogen Receptor/ERR
Tyrosine Kinases
Wnt/beta-catenin
Opioid Receptor
BCL
MMP
Phospholipase
HMG-CoA Reductase
TAM Receptor
ATPase
DHFR
p38 MAPK
Estrogen/progestogen Receptor
P2Y Receptor
GSK-3
Antifolate
ERK
iGluR
Glucocorticoid Receptor
Bcr-Abl
Gamma-secretase
Interleukin
TGF-beta/Smad
AChE
GABA Receptor
MEK
Ras
Tyrosinase
HIF/HIF Prolyl-Hydroxylase
Carbonic Anhydrase
Reductase
MRP
Serine/threonin kinase
NMDAR
IGF-1R
P-gp
HSP
Sirtuin
Nrf2
c-RET
Microtubule Associated
Thrombin
NOS
DNA-PK
NADPH
JNK
PKA
Rho
Cysteine Protease
TRP/TRPV Channel
MAO
E1/E2/E3 Enzyme
Drug Metabolite
Glucosidase
Mitochondrial Metabolism
ROS
Fatty Acid Synthase
FAAH
CXCR
Lipoxygenase
Norepinephrine
DNA
GluCls
Beta Amyloid
c-Fms
GPR
IRAK
PD-1/PD-L1
NO Synthase
HER
Proton pump
Amino Acids and Derivatives
LPL Receptor
Lipase
ABC
CaSR
PARP
Serine Protease
Serotonin Transporter
NAMPT
Glucokinase
CSF-1R
P2X Receptor
BTK
DPP-4
IL Receptor
PTEN
Chk
OX Receptor
GluR
CaMK
Androgen Receptor
Telomerase
SGLT
Trk receptor
Histone Acetyltransferase
transporter
PAI-1
Casein Kinase
IκB/IKK
ATM/ATR
Acetyl-CoA Carboxylase
Ligand for E3 Ligase
CRISPR/Cas9
PDK
Hydroxylase
PLK
Cannabinoid Receptor
Gap Junction Protein
Platelet aggregation
DNA Methyltransferase
S6 Kinase
Protease-activated Receptor
lysosomal autophagy
FAK
NOD-like Receptor (NLR)
p53
S1P Receptor
Kinesin
Thyroid hormone receptor(THR)
Mdm2
Chloride channel
Taste receptor
PROTACs
NPC1L1
ROR
NEDD8
CRM1
Ligands for Target Protein for PROTAC
YAP
IFNAR
Na+/Ca2+ Exchanger
RAR/RXR 
Cell wall
PERK
CETP
Tie-2
gp120/CD4
Glutathione Peroxidase
TOPK
GTPase
VDA
Melatonin Receptor
GNRH Receptor
Hck
cell cycle arrest
FXR
Stemness kinase
Glutaminase
IAP
IRE1
Annexin A
Adiponectin receptor
UGT
Fas/FasL
LDL
MT Receptor
Phosphorylase
DNA gyrase
Molecular Glues
Guanylate cyclase
Integrase
PROTAC Linker
Bombesin Receptor
PAK
Thioredoxin
Hedgehog/Smoothened
Stearoyl-CoA Desaturase (SCD)
PGC-1α
Bradykinin Receptor
Vasopressin Receptor
Endothelin Receptor
ACK
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cAMP
ATP Citrate Lyase
Lipid
PGE Synthase
Glutathione reductase
MAPK
Acyltransferase
OAT
MNK
Survivin
GPCR19
Aminopeptidase
Decarboxylase
ASK
Pyroptosis
ALK
RSV
Neprilysin
GST
Retinoid Receptor
LPA Receptor
Aromatase
PI4K
HIF
Complement System
Neurokinin receptor
Discoidin Domain Receptor (DDR)
Syk
NADPH-oxidase
Sigma receptor
cholecystokinin
AhR
CFTR
MLK

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