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Methoxamine hydrochloride

Name: Methoxamine hydrochloride
Brand: TargetMol
SKU: T0993
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0993Cas No. 61-16-5

Alias Methoxamine HCl

Methoxamine hydrochloride (Methoxamine HCl) is an alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION.

Methoxamine hydrochloride

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Purity: 99.84%

Catalog No. T0993Alias Methoxamine HClCas No. 61-16-5

Methoxamine hydrochloride (Methoxamine HCl) is an alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$38	In Stock	In Stock
25 mg	$48	In Stock	In Stock
50 mg	$85	In Stock	In Stock
100 mg	$148	In Stock	In Stock
200 mg	$209	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$33	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.84%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Methoxamine hydrochloride AI Summary

Methoxamine hydrochloride demonstrates versatile bioactivities across various assays. It exhibits antiplasmodial activity against Plasmodium falciparum W2 with an IC50 value of 10000.0 nM as determined by the SYBR green assay. Additionally, it shows potency in inhibiting the Menin-MLL interaction in leukemia, the ERK signaling pathway, influenza NS1 protein function, Bloom's syndrome helicase, histone lysine methyltransferase G9a, HP1-beta chromodomain interactions, and various other targets. It has been validated as negative for Drug Induced Liver Injury (DILI) based on Pfizer data. The compound also inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells, with inhibition percentages of 104.73% and 80.21% at 10 uM, respectively. However, it shows low bioactivity in inhibiting cell viability in SARS-CoV-2 infected Vero E6 cells with an inhibition index of 0.01818 and exhibits a modest inhibition of the SARS-CoV-2 3CL-Pro protease by 11.38% at 20 µM. Moreover, it demonstrates minor antiviral activity against SARS-CoV-2-induced cytotoxicity in Caco-2 cells and VERO-6 cells, with low inhibition rates of -8.34% and 0.11%, respectively, after 48 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Methoxamine hydrochloride (Methoxamine HCl) is an alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION.
Synonyms	Methoxamine HCl

Chemical Properties

Molecular Weight	247.719
Formula	C₁₁H₁₈ClNO₃
Cas No.	61-16-5
Smiles	Cl.COc1ccc(OC)c(c1)C(O)C(C)N
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 166.7 mg/mL (672.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0368 mL	20.1842 mL	40.3683 mL	201.8416 mL
5 mM	0.8074 mL	4.0368 mL	8.0737 mL	40.3683 mL
10 mM	0.4037 mL	2.0184 mL	4.0368 mL	20.1842 mL
20 mM	0.2018 mL	1.0092 mL	2.0184 mL	10.0921 mL
50 mM	0.0807 mL	0.4037 mL	0.8074 mL	4.0368 mL
100 mM	0.0404 mL	0.2018 mL	0.4037 mL	2.0184 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc