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Diflunisal

Name: Diflunisal
Brand: TargetMol
SKU: T0808
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0808Cas No. 22494-42-4

Alias MK-647, Fluniget, Flovacil, Dolobis, Dolobid

Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.

Diflunisal

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Purity: 99.42%

Catalog No. T0808Alias MK-647, Fluniget, Flovacil, Dolobis, DolobidCas No. 22494-42-4

Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$43	In Stock	In Stock
100 mg	$61	In Stock	In Stock
200 mg	$89	In Stock	In Stock
500 mg	$148	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.42%

Color:White

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COA

Product Introduction

Bioactivity

Description	Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.
Targets&IC50	p300:996 μM
In vitro	Diflunisal, an FDA-approved drug containing a salicylic acid substructure, inhibited CBP/p300 more potently than salicylate. Diflunisal exhibits anti-tumor activity against a specific leukemia carrying a t(8;21) translocation, a tumor previously reported to be dependent on p300 in vitro and in vivo[2].
In vivo	Diflunisal-mediated kinetic stabilization of TTR(Rate-limiting transthyretin) should ameliorate TTR amyloidoses, provided that the nonsteroidal anti-inflammatory drug liabilities can be managed clinically[3].
Cell Research	HEK293T cells are transfected with expression vectors for WT p300 or catalitycally inactive mutant. 24 hr after transfection, cells are treated with diflunisal as indicated for 24 hr. H2B acetylation is measured by Western Blot using specified antibodies. Experiments are repeated four times. (Only for Reference)
Synonyms	MK-647, Fluniget, Flovacil, Dolobis, Dolobid

Chemical Properties

Molecular Weight	250.20
Formula	C₁₃H₈F₂O₃
Cas No.	22494-42-4
Smiles	OC(=O)c1cc(ccc1O)-c1ccc(F)cc1F
Relative Density.	1.437g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (199.84 mM), Sonication is recommended.

Ethanol: 20 mg/mL (79.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9968 mL	19.9840 mL	39.9680 mL	199.8401 mL
5 mM	0.7994 mL	3.9968 mL	7.9936 mL	39.9680 mL
10 mM	0.3997 mL	1.9984 mL	3.9968 mL	19.9840 mL
20 mM	0.1998 mL	0.9992 mL	1.9984 mL	9.9920 mL
50 mM	0.0799 mL	0.3997 mL	0.7994 mL	3.9968 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0400 mL	0.1998 mL	0.3997 mL	1.9984 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc