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(E)-Methyl 4-coumarate

Name: (E)-Methyl 4-coumarate
Brand: TargetMol
SKU: T3733
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3733Cas No. 19367-38-5

Alias OMpCA, Methyl trans-p-Coumarat, Methyl 4-hydroxycinnamate

Methyl (E)-4-hydroxycinnamatee is found in several plants such as onion or Morinda citrifolia. It induces apoptosis in combination with Carnosic Acid and kills acute myeloid leukemia cells. It has antioxidant and antibacterial activity.

(E)-Methyl 4-coumarate

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Purity: 99.97%

Catalog No. T3733Alias OMpCA, Methyl trans-p-Coumarat, Methyl 4-hydroxycinnamateCas No. 19367-38-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$40	-	In Stock
10 g	$58	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.97%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

(E)-Methyl 4-coumarate AI Summary

(E)-Methyl 4-coumarate exhibits a variety of bioactivities across different cell lines and organisms. It induces NAD(P)H quinone reductase activity in cultured Hepa 1c1c7 murine hepatoma cells with an effective concentration (CD) of 83.0 µM. It demonstrates antitumor activity against KB and KBv200 cells with IC50 values of 123,100.0 nM and 101,200.0 nM, respectively. It inhibits 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells, showing the most potent inhibition at a 10:1 molar ratio relative to TPA. Additionally, (E)-Methyl 4-coumarate exerts antiproliferative effects on mouse Colon 26-L5 cells and human HT1080 cells with ED50 values of 84.2 µM and over 100.0 µM, respectively. The compound also reveals antimicrobial activities against fungi Athelia rolfsii and Pythium sp., with significant growth inhibition at 100 ppm and no activity at 10 ppm for Pythium sp. It demonstrates antimutagenic activity in Salmonella Typhimurium TA100 and modest antioxidant potential with an IC50 value greater than 200.0 µg.mL-1. (E)-Methyl 4-coumarate inhibits various human carbonic anhydrase isoforms with Ki values ranging from 780.0 nM to 850.0 nM and shows antiadipogenic activity with an IC50 value of 118,800.0 nM. Moreover, (E)-Methyl 4-coumarate exhibits antibacterial activity against Mycobacterium species, including M. smegmatis, M. bovis BCG, and M. tuberculosis H37Rv, with MIC values of > 600,000 nM, 337,000 nM, and 224,000 nM respectively, and a selectivity index of 2.72. It also inhibits Pseudomonas aeruginosa enzymes PqsD and PqsH, showing 22.0% inhibition of PqsD at 50 µM and less than 10.0% inhibition of PqsH transposon mutant at 250 µM. (E)-Methyl 4-coumarate acts as an inhibitor of human tyrosinase with an IC50 value of 30,000.0 nM in both neonatal human epidermal melanocytes and after 120 minutes in general assays, indicating potential applications in skin whitening and anti-pigmentation treatments. Lastly, it displays cytotoxicity against various cell lines, stability in MeOH and H2O2, antioxidant properties in rat liver microsomes, and anti-inflammatory activity by inhibiting LPS-induced nitric oxide production in murine RAW264.7 cells at 50 µM with less than 50.0% inhibition..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Methyl (E)-4-hydroxycinnamatee is found in several plants such as onion or Morinda citrifolia. It induces apoptosis in combination with Carnosic Acid and kills acute myeloid leukemia cells. It has antioxidant and antibacterial activity.
Synonyms	OMpCA, Methyl trans-p-Coumarat, Methyl 4-hydroxycinnamate

Chemical Properties

Molecular Weight	178.18
Formula	C₁₀H₁₀O₃
Cas No.	19367-38-5
Smiles	C(=C/C(OC)=O)\C1=CC=C(O)C=C1
Relative Density.	1.197 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Chloroform: Soluble

DMSO: 55 mg/mL (308.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6123 mL	28.0615 mL	56.1230 mL	280.6151 mL
5 mM	1.1225 mL	5.6123 mL	11.2246 mL	56.1230 mL
10 mM	0.5612 mL	2.8062 mL	5.6123 mL	28.0615 mL
20 mM	0.2806 mL	1.4031 mL	2.8062 mL	14.0308 mL
50 mM	0.1122 mL	0.5612 mL	1.1225 mL	5.6123 mL
100 mM	0.0561 mL	0.2806 mL	0.5612 mL	2.8062 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc