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TargetMol | Compound Library

Osteogenesis Compound Library

Catalog No. L7900

Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts. The equilibrium between bone formation and resorption is necessary and depends on the action of several local and systemic factors including hormones, cytokines, chemokines, and biomechanical stimulation. An imbalance between bone resorption and formation can result in bone diseases including osteoporosis. Osteoblasts are the main functional cells of bone formation and are responsible for the synthesis, secretion and mineralization of bone matrix. Osteoblasts undergo four stages of osteoblast proliferation, extracellular matrix maturation, extracellular matrix mineralization, and osteoblast apoptosis during bone formation. Many factors are involved in these stages to ultimately regulate bone formation. Multiple signaling pathways were found to be involved in osteogenic proliferation and differentiation. Among them, BMP-SMAD, Wnt/β-Catenin, Notch, Hedgehog, MAPK, and FGF signaling pathways play the most critical roles in regulating osteogenic differentiation. Osteogenesis Compound Library from TargetMol collects 490 osteogenesis related bioactive compounds that can be used for research in bone formation and drug screening.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L7900

Osteogenesis Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 490 osteogenesis related compounds for high throughput and high content screening;
  • Targets several signaling pathways, such as BMP-SMAD, Notch, MAPK, Wnt/β-catenin, Hedgehog, FGF, etc.;
  • Effective tool for research in bone formation and related bone diseases, such as osteoporosis, bone tumor, etc.;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

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Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

Wnt/beta-catenin
p38 MAPK
FGFR
TGF-beta/Smad
Autophagy
Apoptosis
MAPK
Hedgehog/Smoothened
VEGFR
PDGFR
NF-κB
ALK
Src
Gamma-secretase
ERK
Akt
c-Kit
PARP
FLT
Smo
CDK
JNK
TNF
Aurora Kinase
Endogenous Metabolite
GSK-3
Antibacterial
COX
EGFR
Bcr-Abl
Casein Kinase
Parasite
Antibiotic
Reactive Oxygen Species
STAT
Antifungal
Caspase
c-Fms
c-RET
JAK
PKC
Raf
Antiviral
ASK
DNA/RNA Synthesis
MEK
mTOR
S6 Kinase
AMPK
Bcl-2 Family
c-Met/HGFR
FAK
Hippo pathway
IGF-1R
IL Receptor
Porcupine
Sodium Channel
Antioxidant
ATPase
Beta Amyloid
Calcium Channel
Chk
Epigenetic Reader Domain
Mitophagy
MMP
NO Synthase
PKA
PPAR
TLR
5-HT Receptor
Antifection
Carbonic Anhydrase
GABA Receptor
HCV Protease
HDAC
HER
HIV Protease
Influenza Virus
IκB/IKK
Lipid
Lipoxygenase
Mitochondrial Metabolism
MLK
Nrf2
P-gp
PI3K
Prostaglandin Receptor
PROTACs
Ras
Serine Protease
Syk
TAM Receptor
Topoisomerase
Tyrosine Kinases
Virus Protease
AAK1
ABC Transporter
ACK1
Adenylyl Cyclase
Apelin receptor
Arginase
Aromatase
CCR
c-Myc
CSF-1R
Cytochromes P450
Dehydrogenase
DHFR
Discoidin Domain Receptor (DDR)
DNA
DNA Alkylation
Drug Metabolite
DYRK
Estrogen/progestogen Receptor
Ferroptosis
Glucosidase
gp120/CD4
HBV
Hck
HSP
Immunology/Inflammation related
IRAK
Kinesin
LDL
MELK
Methionine Adenosyltransferase (MAT)
Microtubule Associated
MNK
MyD88
NOD-like Receptor (NLR)
p53
PAI-1
Phosphatase
PLK
Potassium Channel
Proton pump
PTEN
PYK2
Rho
RIP kinase
Serine/threonin kinase
Tie-2
transporter
Trk receptor
TRP/TRPV Channel
Kras
BTK