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3-Methyl-2-oxovaleric acid

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Catalog No. T8264Cas No. 1460-34-0

3-Methyl-2-oxovaleric acid is an abnormal metabolite from the incomplete breakdown of branched-chain amino acids. It acts as a neurotoxin, acidogen, and metabotoxin, with the potential to cause nerve cell damage and various metabolic disturbances.

3-Methyl-2-oxovaleric acid

3-Methyl-2-oxovaleric acid

🥰Excellent
Purity: 99.67%
Catalog No. T8264Cas No. 1460-34-0
3-Methyl-2-oxovaleric acid is an abnormal metabolite from the incomplete breakdown of branched-chain amino acids. It acts as a neurotoxin, acidogen, and metabotoxin, with the potential to cause nerve cell damage and various metabolic disturbances.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 mg$30In StockIn Stock
100 mg$40In StockIn Stock
200 mg$56In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.67%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
3-Methyl-2-oxovaleric acid is an abnormal metabolite from the incomplete breakdown of branched-chain amino acids. It acts as a neurotoxin, acidogen, and metabotoxin, with the potential to cause nerve cell damage and various metabolic disturbances.
Chemical Properties
Molecular Weight130.14
FormulaC6H10O3
Cas No.1460-34-0
SmilesCCC(C)C(=O)C(O)=O
Relative Density.1.087g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 105 mg/mL (806.82 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (30.74 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM7.6840 mL38.4202 mL76.8403 mL384.2016 mL
5 mM1.5368 mL7.6840 mL15.3681 mL76.8403 mL
10 mM0.7684 mL3.8420 mL7.6840 mL38.4202 mL
20 mM0.3842 mL1.9210 mL3.8420 mL19.2101 mL
50 mM0.1537 mL0.7684 mL1.5368 mL7.6840 mL
100 mM0.0768 mL0.3842 mL0.7684 mL3.8420 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibitHuman Endogenous MetaboliteEndogenousMetaboliteEndogenous Metabolite3-Methyl-2-oxovaleric acid3Methyl2oxovaleric acid3 Methyl 2 oxovaleric acid
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