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Anti-PTPN12 Polyclonal Antibody

Catalog No. TMAB-11925 Copy Product Info
🥰Excellent
Anti-PTPN12 Polyclonal Antibody is a Rabbit antibody targeting PTPN12. Anti-PTPN12 Polyclonal Antibody can be used in WB.

Anti-PTPN12 Polyclonal Antibody

Copy Product Info
🥰Excellent
Catalog No. TMAB-11925

Anti-PTPN12 Polyclonal Antibody is a Rabbit antibody targeting PTPN12. Anti-PTPN12 Polyclonal Antibody can be used in WB.

Anti-PTPN12 Polyclonal Antibody
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2227-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5277-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-PTPN12 Polyclonal Antibody is a Rabbit antibody targeting PTPN12. Anti-PTPN12 Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human (predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep)
Verified Activity
1. Sample: 293T (Human) Cell Lysate at 30 μg
Primary: Anti-PTPN12 (TMAB-11925) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 88 kD
Observed band size: 74 kD
2. Sample:
293T (Human) Cell Lysate at 30 μg
A431 (Human) Cell Lysate at 30 μg
HepG2 (Human) Cell Lysate at 30 μg
Primary: Anti-PTPN12 (TMAB-11925) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 88 kD
Observed band size: 72 kD
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human PTPN12
Antigen Species
Human
Gene Name
PTPN12
Gene ID
5782
Protein Name
Tyrosine-protein phosphatase non-receptor type 12
Uniprot ID
Q05209
Function
Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2.
Chemical Properties
Molecular WeightTheoretical: 88 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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