RIP2 Kinase Inhibitor 4

Name: RIP2 Kinase Inhibitor 4
Brand: TargetMol
SKU: T39574
Rating: 4.5 (1 reviews)

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Catalog No. T39574Cas No. 2126803-41-4

RIP2 Kinase Inhibitor 4 is a highly potent and selective RIPK2 PROTAC compound that efficiently degrades RIPK2 (pIC50 value of 8) and effectively inhibits the release of TNF-α.

RIP2 Kinase Inhibitor 4

😃Good

Catalog No. T39574Cas No. 2126803-41-4

RIP2 Kinase Inhibitor 4 is a highly potent and selective RIPK2 PROTAC compound that efficiently degrades RIPK2 (pIC50 value of 8) and effectively inhibits the release of TNF-α.

Pack Size	Price	Availability	Quantity
25 mg	Inquiry	Backorder

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Product Introduction

Bioactivity

Description	RIP2 Kinase Inhibitor 4 is a highly potent and selective RIPK2 PROTAC compound that efficiently degrades RIPK2 (pIC50 value of 8) and effectively inhibits the release of TNF-α.
Targets&IC50	RIPK2:8 (pIC50)
In vitro	RIP2 Kinase Inhibitor 4 (Compound 20) is a novel inhibitor targeting the apoptosis (IAP) binder, with reduced binding to the cIAP1 and XIAP BIR3 domains but enhanced binding to the XIAP BIR2 domain[1]. Additionally, it recruits IAP E3 ligases and significantly reduces MDP-induced TNFα production in human PBMCs, with a pIC50 value of 9.3[1].
In vivo	The initial in vivo evaluation of RIP2 Kinase Inhibitor 4 (Compound 20) in rats, administered subcutaneously at a dose of 0.5 mg/kg, showed significant degradation of RIPK2 and suppression of MDP-induced TNFα release after 48 hours[1].

Chemical Properties

Molecular Weight	1045.23
Formula	C₅₀H₆₆F₂N₁₄O₇S
Cas No.	2126803-41-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc