Shopping Cart
Remove All
Your shopping cart is currently empty
RIP2 Kinase Inhibitor 4
😃Good
Catalog No. T39574Cas No. 2126803-41-4
RIP2 Kinase Inhibitor 4 is a highly potent and selective RIPK2 PROTAC compound that efficiently degrades RIPK2 (pIC50 value of 8) and effectively inhibits the release of TNF-α.
RIP2 Kinase Inhibitor 4
😃Good
Catalog No. T39574Cas No. 2126803-41-4
RIP2 Kinase Inhibitor 4 is a highly potent and selective RIPK2 PROTAC compound that efficiently degrades RIPK2 (pIC50 value of 8) and effectively inhibits the release of TNF-α.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | Inquiry | Inquiry | Inquiry |
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Resource Download
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | RIP2 Kinase Inhibitor 4 is a highly potent and selective RIPK2 PROTAC compound that efficiently degrades RIPK2 (pIC50 value of 8) and effectively inhibits the release of TNF-α. |
| Targets&IC50 | RIPK2:8 (pIC50) |
| In vitro | RIP2 Kinase Inhibitor 4 (Compound 20) is a novel inhibitor targeting the apoptosis (IAP) binder, with reduced binding to the cIAP1 and XIAP BIR3 domains but enhanced binding to the XIAP BIR2 domain[1]. Additionally, it recruits IAP E3 ligases and significantly reduces MDP-induced TNFα production in human PBMCs, with a pIC50 value of 9.3[1]. |
| In vivo | The initial in vivo evaluation of RIP2 Kinase Inhibitor 4 (Compound 20) in rats, administered subcutaneously at a dose of 0.5 mg/kg, showed significant degradation of RIPK2 and suppression of MDP-induced TNFα release after 48 hours[1]. |
| Molecular Weight | 1045.23 |
| Formula | C50H66F2N14O7S |
| Cas No. | 2126803-41-4 |
| Smiles | CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)Nc1c(F)cccc1F)NC(=O)c1cnc(cn1)N1CCN(CCCOc2cc3ncnc(Nc4n[nH]c(C)c4C)c3cc2S(=O)(=O)C(C)(C)C)CC1)C(C)(C)C |@@:70| |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy RIP2 Kinase Inhibitor 4 | purchase RIP2 Kinase Inhibitor 4 | RIP2 Kinase Inhibitor 4 cost | order RIP2 Kinase Inhibitor 4 | RIP2 Kinase Inhibitor 4 chemical structure | RIP2 Kinase Inhibitor 4 in vivo | RIP2 Kinase Inhibitor 4 in vitro | RIP2 Kinase Inhibitor 4 formula | RIP2 Kinase Inhibitor 4 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.