Shopping Cart

Your shopping cart is currently empty

Thioridazine hydrochloride

Name: Thioridazine hydrochloride
Brand: TargetMol
SKU: T0365
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T0365Cas No. 130-61-0

Alias Mellaril, Aldazine

Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.

Thioridazine hydrochloride

Copy Product Info

🥰Excellent

Purity: 99.95%

Catalog No. T0365Alias Mellaril, AldazineCas No. 130-61-0

Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$36	In Stock	In Stock
100 mg	$48	In Stock	In Stock
200 mg	$59	In Stock	In Stock
500 mg	$81	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.95%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Thioridazine hydrochloride AI Summary

Thioridazine hydrochloride exhibits a broad spectrum of bioactivities across various biological targets and processes. It demonstrates significant antiplasmodial activity against various strains of Plasmodium falciparum, with IC50 values ranging from 3981.07 nM to 12589.25 nM observed through a SYBR green assay after 72 hours of treatment. In addition to its antimalarial effects, Thioridazine hydrochloride shows potency in inhibiting menin-MLL interaction in MLL-related leukemias, Lamin A splicing, Jumonji Domain Containing 2E (JMJD2E), and other targets such as Tyrosyl-DNA Phosphodiesterase (TDP1) and Human Colon Tumor Cells growth. It also modulates miRNAs and affects lipid storage and Tau fibril formation. Moreover, Thioridazine hydrochloride displays high inhibitory effects on sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells, with inhibition percentages of 95.52% and 81.91%, respectively, at a concentration of 10 μM, indicating potential interaction with OATP transporters. From an antiviral perspective, Thioridazine hydrochloride shows mild activity against SARS-CoV-2 with slight inhibition of cytotoxicity in Caco-2 and VERO-6 cells induced by the virus, and a 13.3% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. Nonetheless, it exhibits low effectiveness in SARS-CoV-2 infected Vero E6 cells, with an inhibition index of -0.1314. Additionally, it demonstrates minimal antifungal activity against Candida albicans and Cryptococcus neoformans and limited antibacterial activity against several bacterial strains. Interestingly, Thioridazine hydrochloride also demonstrates antipsychotic activity in squirrel monkeys, indicated by its capability to inhibit conditioned avoidance response (ED50=0.97 mg/kg), suggesting potential applications in psychiatric conditions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.
Synonyms	Mellaril, Aldazine

Chemical Properties

Molecular Weight	407.04
Formula	C₂₁H₂₇ClN₂S₂
Cas No.	130-61-0
Smiles	Cl.CSc1cc2c(Sc3ccccc3N2CCC2CCCCN2C)cc1
Relative Density.	1.1227 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (135.12 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.91 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4568 mL	12.2838 mL	24.5676 mL	122.8381 mL
5 mM	0.4914 mL	2.4568 mL	4.9135 mL	24.5676 mL
10 mM	0.2457 mL	1.2284 mL	2.4568 mL	12.2838 mL
20 mM	0.1228 mL	0.6142 mL	1.2284 mL	6.1419 mL
50 mM	0.0491 mL	0.2457 mL	0.4914 mL	2.4568 mL
100 mM	0.0246 mL	0.1228 mL	0.2457 mL	1.2284 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc