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Anti-CD48 Antibody
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Catalog No. T9901A-1257 Copy Product Info
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Anti-CD48 Antibody is a humanized monoclonal antibody targeting CD48 (SLAMF2/BLAST-1). CD48 is a GPI-anchored cell surface glycoprotein belonging to the Signaling Lymphocyte Activation Molecule (SLAM) family, widely expressed on lymphocytes, monocytes, and endothelial cells. It serves as a high-affinity ligand for the NK cell receptor 2B4 (CD244) and the T cell receptor CD2, playing a role in mediating immune cell adhesion, activation, and co-stimulatory signaling. Research indicates that CD48 is highly expressed on the surface of hematologic malignancies such as multiple myeloma (MM). By specifically binding to CD48, Anti-CD48 Antibody not only blocks its interaction with ligands but also induces potent Antibody-Dependent Cellular Cytotoxicity (ADCC) and Complement-Dependent Cytotoxicity (CDC), leading to direct tumor cell killing. It is a significant candidate tool for researching immunotherapy in hematological cancers.
Anti-CD48 Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $238 | Inquiry | Inquiry | |
| 5 mg | $718 | Inquiry | Inquiry | |
| 10 mg | $1,150 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-CD48 Antibody is a humanized monoclonal antibody targeting CD48 (SLAMF2/BLAST-1). CD48 is a GPI-anchored cell surface glycoprotein belonging to the Signaling Lymphocyte Activation Molecule (SLAM) family, widely expressed on lymphocytes, monocytes, and endothelial cells. It serves as a high-affinity ligand for the NK cell receptor 2B4 (CD244) and the T cell receptor CD2, playing a role in mediating immune cell adhesion, activation, and co-stimulatory signaling. Research indicates that CD48 is highly expressed on the surface of hematologic malignancies such as multiple myeloma (MM). By specifically binding to CD48, Anti-CD48 Antibody not only blocks its interaction with ligands but also induces potent Antibody-Dependent Cellular Cytotoxicity (ADCC) and Complement-Dependent Cytotoxicity (CDC), leading to direct tumor cell killing. It is a significant candidate tool for researching immunotherapy in hematological cancers. |
| In vitro | Anti-CD48 Antibody binds CD48 with high specificity and induces significant ADCC and CDC against CD48-positive multiple myeloma cells. It also disrupts the CD48-2B4 interaction, modulating NK cell activation [1][2]. |
| In vivo | In multiple myeloma xenograft models, systemic administration of Anti-CD48 Antibody significantly inhibits tumor growth and prolongs survival without significant toxicity [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | CD48 |
| Isotype | IgG4 (S228P) |
| Recommended Isotype Control |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Anti-CD48 Antibody in vivo | Anti-CD48 Antibody in vitro
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