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Anti-CD209/DC-SIGN Antibody (8Q432)
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Catalog No. TMAY-00445
Alias MGC129965, DC-SIGN1, DC-SIGN, CLEC4L, CDSIGN, CD209 molecule, CD209
Anti-CD209/DC-SIGN Antibody (8Q432) is a Mouse antibody targeting CD209/DC-SIGN. Anti-CD209/DC-SIGN Antibody (8Q432) can be used in ELISA(Cap),FCM.
Anti-CD209/DC-SIGN Antibody (8Q432)
Anti-CD209/DC-SIGN Antibody (8Q432)
😃Good
Catalog No. TMAY-00445Alias MGC129965, DC-SIGN1, DC-SIGN, CLEC4L, CDSIGN, CD209 molecule, CD209
Anti-CD209/DC-SIGN Antibody (8Q432) is a Mouse antibody targeting CD209/DC-SIGN. Anti-CD209/DC-SIGN Antibody (8Q432) can be used in ELISA(Cap),FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $69 | 7-10 days | |
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ELISA(Cap), FCM Reactivity: Human |
| Alias | MGC129965, DC-SIGN1, DC-SIGN, CLEC4L, CDSIGN, CD209 molecule, CD209 |
| Ig Type | Mouse IgG1 |
| Clone | 8Q432 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human CD209 expression on DC. Cells were stained with purified anti-Human CD209, then a PE-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | ELISA(Cap),FCM |
| Recommended Dose | FCM: 1:25-1:100; ELISA(Cap): 1:250-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD209 / DC-SIGN. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin (DC-SIGN), also known as CD209, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has an important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. DC-SIGN also mediates the capture and internalization of viral, bacterial, and fungal pathogens by dendritic cells, such as HIV-1, Ebola virus, cytomegalovirus, Dengue virus, and hepatitis C virus. DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Others Formats | APC/FITC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Protein: Human CD209 / DC-SIGN Protein (Cat# 10200-H01H) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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