Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Norbergenin is a chemical compound. It is the O-demethylated derivative of bergenin. It can be isolated from rhizomes of Bergenia stracheyi.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 96.00 | |
5 mg | In stock | $ 198.00 | |
10 mg | In stock | $ 328.00 | |
25 mg | In stock | $ 558.00 | |
50 mg | In stock | $ 788.00 | |
100 mg | In stock | $ 1,120.00 | |
500 mg | In stock | $ 2,230.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 226.00 |
Description | Norbergenin is a chemical compound. It is the O-demethylated derivative of bergenin. It can be isolated from rhizomes of Bergenia stracheyi. |
In vivo | Study showed that the oral administration of Bergenin (1) and Bergenin (1) at doses of 5, 10, 20, 40 and 80 mg/kg per oral dose inhibit the production of proinflammatory Th1 cytokines (IL-2,?IFN-gamma and TNF-alpha) while as potentiate anti-inflammatory Th2 cytokines (IL-4 and IL-5) in the peripheral blood of adjuvant-induced arthritic balb/c mice.?This shows the potential Th1/Th2 cytokine balancing activity of 1 and 2 which is strongly correlated with their anti-arthritic activity.?At similar dose levels, the effect of 2 was found to be more than that of 1.?The oral LD(0) for 1 and 2 was more than 2000 mg/kg body weight of the mice. |
Molecular Weight | 314.24 |
Formula | C13H14O9 |
CAS No. | 79595-97-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (95.47 mM)
You can also refer to dose conversion for different animals. More
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norbergenin 79595-97-4 Apoptosis Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species TNF IL Receptor radical antioxidant bergenin scavenging inhibit Inhibitor derivative superoxide inhibitor