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Tubulin inhibitor 40
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Catalog No. T209173
Tubulin inhibitor 40 (compound 45) is a tubulin inhibitor with an IC50 value of 1.2 μM. It exhibits selective cytotoxicity against cancer cells and possesses antitumor activity.
Tubulin inhibitor 40
Tubulin inhibitor 40
😃Good
Catalog No. T209173
Tubulin inhibitor 40 (compound 45) is a tubulin inhibitor with an IC50 value of 1.2 μM. It exhibits selective cytotoxicity against cancer cells and possesses antitumor activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Backorder | Backorder | |
| 50 mg | Inquiry | Backorder | Backorder |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | Tubulin inhibitor 40 (compound 45) is a tubulin inhibitor with an IC50 value of 1.2 μM. It exhibits selective cytotoxicity against cancer cells and possesses antitumor activity. |
| In vitro | Tubulin inhibitor 40 exhibits cytotoxic effects on A549, VA13, MCF7, and HEK293T cell lines with IC 50 values of 0.005 μM, 0.008 μM, 0.009 μM, and 0.008 μM, respectively. It impedes tubulin polymerization with an IC 50 of 1.2 μM. Additionally, Tubulin inhibitor 40 (1-25 μM, 24 h) induces changes in cell morphology and tubulin polymerization in A549 cells. |
| In vivo | Tubulin inhibitor 40 (administered intravenously at 20 mg/kg for 5 days) demonstrates antitumor activity. |
| Formula | C19H20N2O5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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