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Afloqualone

Name: Afloqualone
Brand: TargetMol
SKU: T4993
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4993Cas No. 56287-74-2

Alias HQ-495

Afloqualone (HQ-495) is a quinazolinone family GABAergic drug that acts as an agonist of the β subtype of the GABAa receptor, exhibiting sedative and muscle-relaxant effects.

Afloqualone

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Purity: 99.72%

Catalog No. T4993Alias HQ-495Cas No. 56287-74-2

Afloqualone (HQ-495) is a quinazolinone family GABAergic drug that acts as an agonist of the β subtype of the GABAa receptor, exhibiting sedative and muscle-relaxant effects.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$41	In Stock	In Stock
100 mg	$56	In Stock	-
1 mL x 10 mM (in DMSO)	$60	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.72%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Afloqualone (HQ-495) is a quinazolinone family GABAergic drug that acts as an agonist of the β subtype of the GABAa receptor, exhibiting sedative and muscle-relaxant effects.
Synonyms	HQ-495

Chemical Properties

Molecular Weight	283.3
Formula	C₁₆H₁₄FN₃O
Cas No.	56287-74-2
Smiles	Cc1ccccc1-n1c(CF)nc2ccc(N)cc2c1=O
Relative Density.	1.2529 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 33 mg/mL (116.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5298 mL	17.6491 mL	35.2983 mL	176.4914 mL
5 mM	0.7060 mL	3.5298 mL	7.0597 mL	35.2983 mL
10 mM	0.3530 mL	1.7649 mL	3.5298 mL	17.6491 mL
20 mM	0.1765 mL	0.8825 mL	1.7649 mL	8.8246 mL
50 mM	0.0706 mL	0.3530 mL	0.7060 mL	3.5298 mL
100 mM	0.0353 mL	0.1765 mL	0.3530 mL	1.7649 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc