Shopping Cart

Your shopping cart is currently empty

Afloqualone

Name: Afloqualone
Brand: TargetMol
SKU: T4993
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T4993Cas No. 56287-74-2

Alias HQ-495

Afloqualone (HQ-495) is a quinazolinone family GABAergic drug that acts as an agonist of the β subtype of the GABAa receptor, exhibiting sedative and muscle-relaxant effects.

Afloqualone

Copy Product Info

🥰Excellent

Purity: 99.72%

Catalog No. T4993Alias HQ-495Cas No. 56287-74-2

Afloqualone (HQ-495) is a quinazolinone family GABAergic drug that acts as an agonist of the β subtype of the GABAa receptor, exhibiting sedative and muscle-relaxant effects.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$34	In Stock	-
1 mL x 10 mM (in DMSO)	$36	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.72%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Afloqualone AI Summary

Afloqualone exhibits acute toxicity with an LD50 of 315.1 mg/kg, along with CNS depressant activity evidenced by an ED50 of 35.1 mg/kg for inducing loss of righting reflex, 15.6 mg/kg in the rotating rod test, 13.3 mg/kg for protection against electroshock-induced seizures, and 5.4 mg/kg for protection against pentylenetetrazole-induced convulsions. It has antiviral activity against SARS-CoV-2, showing a 42.82% inhibition rate of virus-induced cytotoxicity in Caco-2 cells at a 10 µM concentration after 48 hours. In other assays, it displayed minimal activity: a hit score of 0.1208 in HRCE cells, -1.66% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM, and -0.04% inhibition of virus-induced cytotoxicity in VERO-6 cells at 10 µM concentration after 48 hours. Additionally, Afloqualone shows weak inhibitory effects on human HDAC6, with -2.71% inhibition using a commercial peptide substrate and -10.2% inhibition using a custom peptide substrate, and no significant inhibitory activity or binding affinity in most other tested bioassays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Afloqualone (HQ-495) is a quinazolinone family GABAergic drug that acts as an agonist of the β subtype of the GABAa receptor, exhibiting sedative and muscle-relaxant effects.
Synonyms	HQ-495

Chemical Properties

Molecular Weight	283.3
Formula	C₁₆H₁₄FN₃O
Cas No.	56287-74-2
Smiles	Cc1ccccc1-n1c(CF)nc2ccc(N)cc2c1=O
Relative Density.	1.2529 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 33 mg/mL (116.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5298 mL	17.6491 mL	35.2983 mL	176.4914 mL
5 mM	0.7060 mL	3.5298 mL	7.0597 mL	35.2983 mL
10 mM	0.3530 mL	1.7649 mL	3.5298 mL	17.6491 mL
20 mM	0.1765 mL	0.8825 mL	1.7649 mL	8.8246 mL
50 mM	0.0706 mL	0.3530 mL	0.7060 mL	3.5298 mL
100 mM	0.0353 mL	0.1765 mL	0.3530 mL	1.7649 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc