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3'-Hydroxypterostilbene

Name: 3'-Hydroxypterostilbene
Brand: TargetMol
SKU: T2S2382
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2S2382Cas No. 475231-21-1

Alias 3'-HPT

3'-Hydroxypterostilbene (3'-HPT), a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 μM for COLO 205, HCT-116, and HT-29 cells, respectively, by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the p38MAPK , and PI3K/Akt/mTOR/p70S6K pathways and activates the ERK1/2, JNK1/2 MAPK pathways[1].

3'-Hydroxypterostilbene

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Purity: 99.19%

Catalog No. T2S2382Alias 3'-HPTCas No. 475231-21-1

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	In Stock	In Stock
5 mg	$50	In Stock	In Stock
10 mg	$70	In Stock	In Stock
25 mg	$113	In Stock	In Stock
50 mg	$163	In Stock	In Stock
100 mg	$239	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$60	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.19%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

3'-Hydroxypterostilbene AI Summary

3'-Hydroxypterostilbene inhibits proliferation of HL60 cells with an IC50 of 800.0 nM in vitro and induces apoptosis in these cells with an AC50 of 1000.0 nM. In addition to its antiproliferative and pro-apoptotic properties, 3'-Hydroxypterostilbene exhibits notable antioxidant activity, with a high inhibition rate constant of 110.0 x 10^4 L/mol/s for reactions with peroxyl radicals. It also offers cytoprotective effects against hypoxia-induced toxicity in rat H9c2 cells, enhancing cell viability by 25.0% at a concentration of 80 nM after preincubation for 18 hours and 48 hours of hypoxia exposure. Furthermore, 3'-Hydroxypterostilbene inhibits human 5-lipoxygenase (5-LOX) with an IC50 of 320.0 nM in Escherichia coli BL21 using arachidonic acid as a substrate, and significantly inhibits 5-LOX activity in human polymorphonuclear leukocytes (PMNL) with an IC50 of 50.0 nM, as assessed by A23187-stimulated leukotriene B4 (LTB4) production..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	3'-Hydroxypterostilbene (3'-HPT), a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 μM for COLO 205, HCT-116, and HT-29 cells, respectively, by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the p38MAPK , and PI3K/Akt/mTOR/p70S6K pathways and activates the ERK1/2, JNK1/2 MAPK pathways[1].
Synonyms	3'-HPT

Chemical Properties

Molecular Weight	272.3
Formula	C₁₆H₁₆O₄
Cas No.	475231-21-1
Smiles	COc1cc(OC)cc(\C=C\c2ccc(O)c(O)c2)c1
Relative Density.	1.251 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (201.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6724 mL	18.3621 mL	36.7242 mL	183.6210 mL
5 mM	0.7345 mL	3.6724 mL	7.3448 mL	36.7242 mL
10 mM	0.3672 mL	1.8362 mL	3.6724 mL	18.3621 mL
20 mM	0.1836 mL	0.9181 mL	1.8362 mL	9.1811 mL
50 mM	0.0734 mL	0.3672 mL	0.7345 mL	3.6724 mL
100 mM	0.0367 mL	0.1836 mL	0.3672 mL	1.8362 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc