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2'-Deoxycytidine hydrochloride

🥰Excellent
Catalog No. T22494Cas No. 3992-42-5
Alias Deoxyribose cytidine hydrochloride, Deoxycytidine hydrochloride, Cytosine deoxyriboside hydrochloride

2'-Deoxycytidine hydrochloride is the hydrochloride form of 2'-Deoxycytidine, an important deoxyribonucleoside analog commonly used in DNA synthesis and potentially anticancer, and its derivative Gemcitabine has been developed as an anticancer drug.2'-Deoxycytidine 2'-Deoxycytidine hydrochloride protects mice from the lethal toxicity of cytosine arabinoside(araC).

2'-Deoxycytidine hydrochloride
Other Forms of 2'-Deoxycytidine hydrochloride:
2'-DeoxycytidineT4758951-77-9
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2'-Deoxycytidine hydrochloride

🥰Excellent
Purity: 98.96%
Catalog No. T22494Alias Deoxyribose cytidine hydrochloride, Deoxycytidine hydrochloride, Cytosine deoxyriboside hydrochlorideCas No. 3992-42-5
2'-Deoxycytidine hydrochloride is the hydrochloride form of 2'-Deoxycytidine, an important deoxyribonucleoside analog commonly used in DNA synthesis and potentially anticancer, and its derivative Gemcitabine has been developed as an anticancer drug.2'-Deoxycytidine 2'-Deoxycytidine hydrochloride protects mice from the lethal toxicity of cytosine arabinoside(araC).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
200 mg$29-In Stock
1 mL x 10 mM (in DMSO)$29-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.96%
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Product Introduction

Bioactivity
Description
2'-Deoxycytidine hydrochloride is the hydrochloride form of 2'-Deoxycytidine, an important deoxyribonucleoside analog commonly used in DNA synthesis and potentially anticancer, and its derivative Gemcitabine has been developed as an anticancer drug.2'-Deoxycytidine 2'-Deoxycytidine hydrochloride protects mice from the lethal toxicity of cytosine arabinoside(araC).
In vitro
Methods: Effects of 2'-Deoxycytidine hydrochloride (1 mM) on the cytotoxicity of 5FU against mouse myeloma SP2/0-Ag14 (SP2/0) cells lacking hypoxanthine-guanine-phosphoribosyltransferase (HGPRT) and RH4 hybridoma cells possessing HGPRT under asynchronous conditions.
Results: In both SP2/0 and RH4 cells, 5FU-reduced cell viability was restored by co-treatment but not pre-treatment with 2'-Deoxycytidine hydrochloride, but the effect of the former was often greater than that of the latter, suggesting that HGPRT may be involved in the interaction, although this may not be the primary mechanism. [1]
SynonymsDeoxyribose cytidine hydrochloride, Deoxycytidine hydrochloride, Cytosine deoxyriboside hydrochloride
Chemical Properties
Molecular Weight263.68
FormulaC9H14ClN3O4
Cas No.3992-42-5
SmilesO=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=CC(N)=N1.Cl
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture | store at 4°C | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 30 mg/mL (113.77 mM), Sonication is recommended.
DMSO: 20 mg/mL (75.85 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.58 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM3.7925 mL18.9624 mL37.9248 mL189.6238 mL
5 mM0.7585 mL3.7925 mL7.5850 mL37.9248 mL
10 mM0.3792 mL1.8962 mL3.7925 mL18.9624 mL
20 mM0.1896 mL0.9481 mL1.8962 mL9.4812 mL
50 mM0.0758 mL0.3792 mL0.7585 mL3.7925 mL
H2O
1mg5mg10mg50mg
100 mM0.0379 mL0.1896 mL0.3792 mL1.8962 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

2'-Deoxycytidine Hydrochloride2'Deoxycytidine hydrochloride2' Deoxycytidine hydrochloride
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