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Anti-OAS2 Polyclonal Antibody
😃Good
Catalog No. TMAB-09726
Anti-OAS2 Polyclonal Antibody is a Rabbit antibody targeting OAS2. Anti-OAS2 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-OAS2 Polyclonal Antibody
Anti-OAS2 Polyclonal Antibody
😃Good
Catalog No. TMAB-09726
Anti-OAS2 Polyclonal Antibody is a Rabbit antibody targeting OAS2. Anti-OAS2 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-OAS2 Polyclonal Antibody is a Rabbit antibody targeting OAS2. Anti-OAS2 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Dog,Pig) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum.Note=Associated with different subcellular fractions such asmitochondrial, nuclear, and rough/smooth microsomal fractions. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated synthetic peptide: human OAS2 |
| Antigen Species | Human |
| Gene Name | OAS2 |
| Gene ID | |
| Protein Name | 2'-5'-oligoadenylate synthase 2 |
| Uniprot ID | |
| Function | Interferon-induced, dsRNA-activated antiviral enzymewhich plays a critical role in cellular innate antiviral response.In addition, it may also play a role in other cellular processessuch as apoptosis, cell growth, differentiation and generegulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form ofribonuclease L (RNase L) leading to its dimerization and subsequentactivation. Activation of RNase L leads to degradation of cellularas well as viral RNA, resulting in the inhibition of proteinsynthesis, thus terminating viral replication. Can mediate theantiviral effect via the classical RNase L-dependent pathway or analternative antiviral pathway independent of RNase L.[CATALYTIC ACTIVITY] 3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate. |
| Molecular Weight | Theoretical: 82 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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