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Chlorphenesin

Name: Chlorphenesin
Brand: TargetMol
SKU: T4507
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4507Cas No. 104-29-0

Alias Gecophen, Chlorophenesin, Adermykon

Chlorphenesin (Chlorophenesin) is an antigen-associated immunosuppressant that inhibits IgE-mediated histamine release. It is also used as an antimycotic agent.

Chlorphenesin

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Purity: 99.59%

Catalog No. T4507Alias Gecophen, Chlorophenesin, AdermykonCas No. 104-29-0

Chlorphenesin (Chlorophenesin) is an antigen-associated immunosuppressant that inhibits IgE-mediated histamine release. It is also used as an antimycotic agent.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$31	In Stock	In Stock
100 mg	$44	In Stock	In Stock
500 mg	$113	In Stock	In Stock
1 g	$168	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.59%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Chlorphenesin AI Summary

Chlorphenesin exhibits antifungal, antiviral, and enzyme inhibitory activities with several measurable effects. It inhibits the growth of Trichophyton mentagrophytes over a 14-day period using the tube dilution method, with a log(1/C) value of 2.31, and has a n-octanol-water partition coefficient (log P) of 1.4. In antiviral assays, it is noted for its ability to inhibit SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM concentration after 48 hours, though with varying inhibition rates recorded. It exhibits a hit score of -0.006972 in HRCE cells and shows a moderate inhibition of SARS-CoV-2 3CL-Pro protease by 11.8% at 20 µM concentration. Additionally, its inhibitory activity towards the human HDAC6 enzyme was reported to be significant, showing 124.5% inhibition in one assay and a lesser degree of 3.93% in another. Despite binding affinities towards various human and rat receptors and enzymes, no significant bioactivity was observed at the tested concentrations, and it displayed no notable inhibition or agonist/antagonist activity in those instances..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Chlorphenesin (Chlorophenesin) is an antigen-associated immunosuppressant that inhibits IgE-mediated histamine release. It is also used as an antimycotic agent.
Synonyms	Gecophen, Chlorophenesin, Adermykon

Chemical Properties

Molecular Weight	202.63
Formula	C₉H₁₁ClO₃
Cas No.	104-29-0
Smiles	O(CC(CO)O)C1=CC=C(Cl)C=C1
Relative Density.	1.317g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (271.43 mM), Sonication is recommended.

H2O: 49.4 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9351 mL	24.6755 mL	49.3510 mL	246.7552 mL
5 mM	0.9870 mL	4.9351 mL	9.8702 mL	49.3510 mL
10 mM	0.4935 mL	2.4676 mL	4.9351 mL	24.6755 mL
20 mM	0.2468 mL	1.2338 mL	2.4676 mL	12.3378 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0987 mL	0.4935 mL	0.9870 mL	4.9351 mL
100 mM	0.0494 mL	0.2468 mL	0.4935 mL	2.4676 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc