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Thalidomide-4-OH

Name: Thalidomide-4-OH
Brand: TargetMol
SKU: T7763
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7763Cas No. 5054-59-1

Alias E3 ligase Ligand 2, Cereblon ligand 2

Thalidomide-4-OH (E3 ligase Ligand 2) (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) is a linker to form PROTACs

Thalidomide-4-OH

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Purity: 99.59%

Catalog No. T7763Alias E3 ligase Ligand 2, Cereblon ligand 2Cas No. 5054-59-1

Thalidomide-4-OH (E3 ligase Ligand 2) (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) is a linker to form PROTACs

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$29	In Stock	In Stock

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Batch Information

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Purity:99.59%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Thalidomide-4-OH (E3 ligase Ligand 2) (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) is a linker to form PROTACs
In vitro	Thalidomide-OH has weak anti-angiogenic activity. Thalidomide-OH does not have any anti-proliferative effect against the breast or neuroblastoma cells, but do possess appreciable anti-proliferative activity against the endothelial cells[1].
Synonyms	E3 ligase Ligand 2, Cereblon ligand 2

Chemical Properties

Molecular Weight	274.23
Formula	C₁₃H₁₀N₂O₅
Cas No.	5054-59-1
Smiles	OC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O
Relative Density.	1.611 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (109.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (12.03 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6466 mL	18.2329 mL	36.4657 mL	182.3287 mL
5 mM	0.7293 mL	3.6466 mL	7.2931 mL	36.4657 mL
10 mM	0.3647 mL	1.8233 mL	3.6466 mL	18.2329 mL
20 mM	0.1823 mL	0.9116 mL	1.8233 mL	9.1164 mL
50 mM	0.0729 mL	0.3647 mL	0.7293 mL	3.6466 mL
100 mM	0.0365 mL	0.1823 mL	0.3647 mL	1.8233 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc