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Anti-PITX3 Antibody (5L490)
😃Good
Catalog No. TMAH-00982
Alias PTX3, PITX 3, Pituitary homeobox 3, Paired-like homeodomain transcription factor 3, Homeobox protein PITX3
Anti-PITX3 Antibody (5L490) is an antibody targeting PITX3. Anti-PITX3 Antibody (5L490) can be used in ELISA,FCM,IF.
Anti-PITX3 Antibody (5L490)
Anti-PITX3 Antibody (5L490)
😃Good
Catalog No. TMAH-00982Alias PTX3, PITX 3, Pituitary homeobox 3, Paired-like homeodomain transcription factor 3, Homeobox protein PITX3
Anti-PITX3 Antibody (5L490) is an antibody targeting PITX3. Anti-PITX3 Antibody (5L490) can be used in ELISA,FCM,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $209 | 7-10 days | 7-10 days | |
| 100 μL | $349 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-PITX3 Antibody (5L490) is an antibody targeting PITX3. Anti-PITX3 Antibody (5L490) can be used in ELISA,FCM,IF. |
| Synonyms | PTX3, PITX 3, Pituitary homeobox 3, Paired-like homeodomain transcription factor 3, Homeobox protein PITX3 |
| Ig Type | Rabbit IgG |
| Clone | 5L490 |
| Reactivity | Human |
| Verified Activity | 1. Immunofluorescence staining of A549 with TMAH-00982 at 1:20, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 520-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). 2. Overlay Peak curve showing SH-SY5Y cells stained with TMAH-00982 (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1µg/1*10^6 cells) for 45min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4°C.Control antibody (green line) was rabbit IgG (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| Application | |
| Recommended Dose | IF:1:50-1:200; FCM:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Nucleus. |
| Tissue Specificity | Highly expressed in developing eye lens. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human PITX3 |
| Antigen Species | Human |
| Gene Name | PITX3 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Epigenetics and Nuclear Signaling, Neuroscience |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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