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Ecdysone

🥰Excellent
Catalog No. TN3910Cas No. 3604-87-3

Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death.

Ecdysone

Ecdysone

🥰Excellent
Purity: 99.22%
Catalog No. TN3910Cas No. 3604-87-3
Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$103In StockIn Stock
5 mg$321In StockIn Stock
10 mg$468In StockIn Stock
25 mg$750In StockIn Stock
50 mg$1,030In StockIn Stock
100 mg$1,390In StockIn Stock
200 mg$1,880-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.22%
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Product Introduction

Bioactivity
Description
Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death.
In vitro
Ecdysone (10, 100 nM) induced the expression of a-smooth muscle actin (SMA). Ecdysone elevated the expression of cleaved caspase 3 in a dose dependent manner. Ecdysone (10, 100 nM) suppressed cell motility and scratch wound closure to a comparable extent[4]. Ecdysone (100 nM) induced a branched spindle mesenchymal-like cell shape. Ecdysone (100 nM) caused renal tubular inner medullary collecting duct cells apoptosis[4].
In vivo
In male C57BL/6 mice, Ecdysone (6 μg/g/day; s.c.) significantly impaired renal function, and BUN levels were statistically significantly increased, amplifying the renal expression of α-SMA. Ecdysone also displayed MR-dependent nephrotic effects[4].
Chemical Properties
Molecular Weight464.63
FormulaC27H44O6
Cas No.3604-87-3
SmilesC[C@H]([C@@H](CCC(C)(C)O)O)[C@@H](CC1)[C@@](C)(CC[C@H]([C@@](C)(C[C@@H]2O)[C@H]3C[C@H]2O)C2=CC3=O)[C@]12O
Relative Density.1.22g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (129.14 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.15 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1523 mL10.7613 mL21.5225 mL107.6125 mL
5 mM0.4305 mL2.1523 mL4.3045 mL21.5225 mL
10 mM0.2152 mL1.0761 mL2.1523 mL10.7613 mL
20 mM0.1076 mL0.5381 mL1.0761 mL5.3806 mL
50 mM0.0430 mL0.2152 mL0.4305 mL2.1523 mL
100 mM0.0215 mL0.1076 mL0.2152 mL1.0761 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

α-EcdysonetransitionssteroidSodiumChannelSodium ChannelsleepregulationreceptorPotassiumChannelPotassium ChannelMineralocorticoid ReceptormineralocorticoidmetaboliteInhibitorinhibitHuman Endogenous MetabolitehormonehomeostaticGlucocorticoidReceptorGlucocorticoid ReceptorEndogenousMetaboliteEndogenous MetaboliteEcdysonedevelopmentalCrustecdysonecoordinatingAutophagyATPaseApoptosis20-hydroxyecdysone20E
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