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Anti-LILRB4 Monoclonal Antibody-Biotin
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Catalog No. TMAZ-0181B
Alias Monocyte inhibitory receptor HM18, Leukocyte immunoglobulin-like receptor subfamily B member 4, Leukocyte immunoglobulin-like receptor 5, Immunoglobulin-like transcript 3, CD85 antigen-like family member K
Anti-LILRB4 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting LILRB4. Anti-LILRB4 Monoclonal Antibody-Biotin can be used in ELISA,FCM.
Anti-LILRB4 Monoclonal Antibody-Biotin
Anti-LILRB4 Monoclonal Antibody-Biotin
😃Good
Catalog No. TMAZ-0181BAlias Monocyte inhibitory receptor HM18, Leukocyte immunoglobulin-like receptor subfamily B member 4, Leukocyte immunoglobulin-like receptor 5, Immunoglobulin-like transcript 3, CD85 antigen-like family member K
Anti-LILRB4 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting LILRB4. Anti-LILRB4 Monoclonal Antibody-Biotin can be used in ELISA,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μg | $196 | 12 days | 12 days | |
| 50 μg | $236 | 12 days | 12 days | |
| 100 μg | $330 | 12 days | 12 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-LILRB4 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting LILRB4. Anti-LILRB4 Monoclonal Antibody-Biotin can be used in ELISA,FCM. |
| Synonyms | Monocyte inhibitory receptor HM18, Leukocyte immunoglobulin-like receptor subfamily B member 4, Leukocyte immunoglobulin-like receptor 5, Immunoglobulin-like transcript 3, CD85 antigen-like family member K |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of LILRB4 overexpressed 351F cells with TMAZ-0181B, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of LILRB4 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in PBS. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed: 11875462). Receptor for FN1 (PubMed: 34089617). Receptor for apolipoprotein APOE (PubMed: 30333625). Receptor for ALCAM/CD166 (PubMed: 29263213). Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed: 9151699). Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed: 19833736). This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed: 34089617). Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed: 16493035, PubMed: 19833736, PubMed: 29263213). Induces up-regulation of CD86 on dendritic cells (PubMed: 19860908). Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed: 11875462) |
| Conjucates | Biotin |
| Others Formats | Unconjugated |
| Antibody Types Available | 2 |
| Immunogen | LILRB4 |
| Antigen Species | Human |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Drug Target |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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