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Triamcinolone acetonide

Name: Triamcinolone acetonide
Brand: TargetMol
SKU: T0820
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T0820Cas No. 76-25-5

Alias Azmacort, Aristogel, Aristoderm

Triamcinolone acetonide (Azmacort) is a Corticosteroid. The mechanism of action of triamcinolone acetonide is as a Corticosteroid Hormone Receptor Agonist. It is an anti-inflammatory glucocorticoid used topically in the treatment of various skin disorders. Intralesional, intramuscular, and intra-articular injections are also administered under certain conditions.

Triamcinolone acetonide

🥰Excellent

Purity: 99.91%

Catalog No. T0820Alias Azmacort, Aristogel, AristodermCas No. 76-25-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.91%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Triamcinolone acetonide (Azmacort) is a Corticosteroid. The mechanism of action of triamcinolone acetonide is as a Corticosteroid Hormone Receptor Agonist. It is an anti-inflammatory glucocorticoid used topically in the treatment of various skin disorders. Intralesional, intramuscular, and intra-articular injections are also administered under certain conditions.
In vitro	In horses subjected to a second injection of lipopolysaccharide, Triamcinolone Acetonide reduced edema, lameness, and joint fluid protein concentration. In mice, Triamcinolone Acetonide, a synthetic glucocorticoid, induced cleft palate resulting from impaired palatal development. In the jaws of rat embryos, Triamcinolone Acetonide inhibited the proliferation of mesenchymal cells and affected the differentiation of MEE (Medial Edge Epithelium) cells into stratified squamous epithelial cells. Compared to methoxycarbonyl alone, Triamcinolone Acetonide increased both the white blood cell count and methoxycarbonyl concentration in the synovial fluid.
In vivo	Triamcinolone Acetonide reduced polysaccharide synthesis and increased the glycosaminoglycan (GAG) content in the culture medium compared to the blank group and IL-1 group. It also augmented GAG degradation. This compound significantly decreased the paracellular permeability of ECV304 cells and downregulated ICAM-1 expression, corroborating with immunocytochemical observations. In rat retinas, Triamcinolone reversed Müller glial cell swelling, a phenomenon observed under various experimental conditions: in retinas isolated 3 days post-transient retinal ischemia, in control retinas with 1 mM Ba^2+, 10 μM arachidonic acid, 200 μM H2O2, or 30 nM prostaglandin E2, and in retinas with lipopolysaccharide-induced ocular inflammation.
Synonyms	Azmacort, Aristogel, Aristoderm

Chemical Properties

Molecular Weight	434.50
Formula	C₂₄H₃₁FO₆
Cas No.	76-25-5
Smiles	C(CO)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(OC(C)(C)O2)[H])([C@]4([C@](F)([C@@H](O)C3)[C@]5(C)C(CC4)=CC(=O)C=C5)[H])[H]
Relative Density.	1.33 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 13 mg/mL (29.92 mM), Sonication is recommended.

DMSO: 50 mg/mL (115.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.6 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3015 mL	11.5075 mL	23.0150 mL	115.0748 mL
5 mM	0.4603 mL	2.3015 mL	4.6030 mL	23.0150 mL
10 mM	0.2301 mL	1.1507 mL	2.3015 mL	11.5075 mL
20 mM	0.1151 mL	0.5754 mL	1.1507 mL	5.7537 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0460 mL	0.2301 mL	0.4603 mL	2.3015 mL
100 mM	0.0230 mL	0.1151 mL	0.2301 mL	1.1507 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc